Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation

by Shrivastav, Nidhi, Li, Deyu, Essigmann, John M.
Published 2012

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

by Fedeles, Bogdan I., Singh, Vipender, Delaney, James C., Li, Deyu, Essigmann, John M.
Published 2015

Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity

by Peng, Chunte, Fedeles, Bogdan I., Singh, Vipender, Li, Deyu, Amariuta, Tiffany, Essigmann, John M., Tokmakoff, Andrei
Published 2015

Direct Observation of Multiple Tautomers of Oxythiamine and their Recognition by the Thiamine Pyrophosphate Riboswitch

by Singh, Vipender, Peng, Chunte Sam, Li, Deyu, Mitra, Koyel, Silvestre, Katherine J., Tokmakoff, Andrei, Essigmann, John M.
Published 2015

Repair of DNA Alkylation Damage by the Escherichia coli Adaptive AlkB as Studied by ESI-TOF Mass Spectrometry

by Li, Deyu, Delaney, James C., Page, Charlotte M., Chen, Alvin S., Wong, Cintyu, Essigmann, John M., Drennan, Catherine L
Published 2011

Oncometabolites D- and L-2-hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions

by Chen, Fangyi, Bian, Ke, Tang, Qi, Humulock, Zachary T., Li, Deyu, Fedeles, Bogdan I, Singh, Vipender, Essigmann, John M.
Published 2018

Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA

by Chen, Fangyi, Tang, Qi, Bian, Ke, Humulock, Zachary T., Yang, Xuedong, Li, Deyu, Jost, Marco, Drennan, Catherine L., Essigmann, John M.
Published 2018

Removal of N-Alkyl Modifications from N[superscript 2]-Alkylguanine and N[superscript 4]-Alkylcytosine in DNA by the Adaptive Response Protein AlkB

by Li, Deyu, Fedeles, Bogdan I., Shrivastav, Nidhi, Delaney, James C., Yang, Xuedong, Wong, Cintyu, Drennan, Catherine L., Essigmann, John M.
Published 2013

Exocyclic Carbons Adjacent to the N[superscript 6] of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB

by Li, Deyu, Delaney, James C., Page, Charlotte M., Yang, Xuedong, Chen, Alvin S., Wong, Cintyu, Essigmann, John M., Drennan, Catherine L
Published 2012

A Chemical Genetics Analysis of the Roles of Bypass Polymerase DinB and DNA Repair Protein AlkB in Processing N[superscript 2]-Alkylguanine Lesions In Vivo

by Shrivastav, Nidhi, Li, Deyu, Delaney, James C., Frick, Lauren E., Foti, James J., Walker, Graham C., Essigmann, John M., Fedeles, Bogdan I
Published 2014

Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine

by Li, Deyu, Fedeles, Bogdan I., Singh, Vipender, Peng, Chunte Sam, Silvestre, Katherine J., Simi, Allison K., Simpson, Jeffrey H., Essigmann, John M., Tokmakoff, Andrei
Published 2015

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

by Fedeles, Bogdan I., Freudenthal, Bret D., Yau, Emily, Singh, Vipender, Chang, Shiou-chi, Li, Deyu, Delaney, James C., Wilson, Samuel H., Essigmann, John M.
Published 2016

Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB

by Singh, Vipender, Fedeles, Bogdan I., Li, Deyu, Delaney, James C., Kozekov, Ivan D., Kozekova, Albena, Marnett, Lawrence J., Rizzo, Carmelo J., Essigmann, John M.
Published 2015

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro

by Bian, Ke, Lenz, Stefan A P, Tang, Qi, Chen, Fangyi, Qi, Rui, Jost, Marco, Drennan, Catherine L, Essigmann, John M, Wetmore, Stacey D, Li, Deyu
Published 2020