Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities

by Barbara Nuvoli, Barbara Antoniani, Roberta Libener, Antonio Maconi, Andrea Sacconi, Mariantonia Carosi, Rossella Galati
Published 2021-08-01

Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies

by Daniel Strüder, Theresa Momper, Nina Irmscher, Mareike Krause, Jan Liese, Sebastian Schraven, Annette Zimpfer, Sarah Zonnur, Ann-Sophie Burmeister, Björn Schneider, Bernhard Frerich, Robert Mlynski, Christina Große-Thie, Christian Junghanss, Claudia Maletzki
Published 2021-08-01

Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis

by Manuel Pedro Jimenez-García, Antonio Lucena-Cacace, Daniel Otero-Albiol, Amancio Carnero
Published 2021-08-01

Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

by Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak, Paolo Ceppi
Published 2021-08-01

Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells

by Li Ding, Zhiping Zhang, Chenhong Zhao, Lei Chen, Zhiqiang Chen, Jie Zhang, Yaxian Liu, Yesen Nie, Yanzhi He, Kai Liao, Xinyue Zhang
Published 2021-08-01

FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

by Taoyue Yang, Peng Shen, Qun Chen, Pengfei Wu, Hao Yuan, Wanli Ge, Lingdong Meng, Xumin Huang, Yuzhe Fu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu, Kuirong Jiang
Published 2021-08-01

Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer

by Haiyong Zhang, Jing Wu, Jinqiu Yuan, Huafu Li, Yawei Zhang, Wang Wu, Wei Chen, Chunming Wang, Sijun Meng, Songyao Chen, Mingyu Huo, Yulong He, Changhua Zhang
Published 2021-08-01

Altered proTGFα/cleaved TGFα ratios offer new therapeutic strategies in renal carcinoma

by Sara García-Alonso, Inés Romero-Pérez, Lucía Gandullo-Sánchez, Luis Chinchilla, Alberto Ocaña, Juan Carlos Montero, Atanasio Pandiella
Published 2021-08-01

Correction to: Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway

by Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou, Dan Xie
Published 2021-03-01

Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy

by Chrysostomi Gialeli, Emre Can Tuysuz, Johan Staaf, Safia Guleed, Veronika Paciorek, Matthias Mörgelin, Konstantinos S. Papadakos, Anna M. Blom
Published 2021-08-01

CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity

by Valeria Catena, Tiziana Bruno, Simona Iezzi, Silvia Matteoni, Annalisa Salis, Cristina Sorino, Gianluca Damonte, Maurizio Fanciulli
Published 2021-07-01

Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p/FGF2/PI3K/Akt axis

by Bingsheng Yang, Lutao Li, Ge Tong, Zhirui Zeng, Jianye Tan, Zexin Su, Zhengwei Liu, Jiezhao Lin, Wenwen Gao, Jianping Chen, Sisi Zeng, Guofeng Wu, Lin Li, Shuang Zhu, Qiuzhen Liu, Lijun Lin
Published 2021-07-01

Correction to: Current status of ctDNA in precision oncology for hepatocellular carcinoma

by Yan Li, Yuanyuan Zheng, Liwei Wu, Jingjing Li, Jie Ji, Qiang Yu, Weiqi Dai, Jiao Feng, Jianye Wu, Chuanyong Guo
Published 2021-07-01

Retraction Note: Dual loading miR-218 mimics and Temozolomide using AuCOOH@FA-CS drug delivery system: promising targeted antitumor drug delivery system with sequential release fun...

by Li Fan, Qian Yang, Jiali Tan, Youbei Qiao, Qiaofeng Wang, Jingya He, Hong Wu, Yongsheng Zhang
Published 2021-08-01

Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target

by Xuan Xu, Yiming Lei, Lingjun Chen, Haoxiong Zhou, Huiling Liu, Jie Jiang, Yidong Yang, Bin Wu
Published 2021-08-01

Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target

by Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, Olivia Babb, Nikkitha Umesh Ganesh, George Sandusky, Emily Hulsey, Lee Armstrong, Amber L. Mosely, Bumsoo Han, Mircea Ivan, Jing-Ruey Joanna Yeh, Mark R. Kelley, Chi Zhang, Melissa L. Fishel
Published 2021-08-01

Cellular based immunotherapy for primary liver cancer

by Yuanyuan Zheng, Yan Li, Jiao Feng, Jingjing Li, Jie Ji, Liwei Wu, Qiang Yu, Weiqi Dai, Jianye Wu, Yingqun Zhou, Chuanyong Guo
Published 2021-08-01

Correction to: Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway...

by Jun Li, Rumeng Yang, Yuting Dong, Manyao Chen, Yu Wang, Guoping Wang
Published 2021-08-01

Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma

by Fengzhi Li, Ieman A. M. Aljahdali, Renyuan Zhang, Kent L. Nastiuk, John J. Krolewski, Xiang Ling
Published 2021-08-01

XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor

by Lijia Pan, Cheng Cheng, Peiwen Duan, Kai Chen, Yeming Wu, Zhixiang Wu
Published 2021-08-01