Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

by Mark A. T. Blaskovich, Karl A. Hansford, Yujing Gong, Mark S. Butler, Craig Muldoon, Johnny X. Huang, Soumya Ramu, Alberto B. Silva, Mu Cheng, Angela M. Kavanagh, Zyta Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya A. Bradford, June C. Lee, Tomislav Karoli, Ruby Pelingon, David J. Edwards, Maite Amado, Alysha G. Elliott, Wanida Phetsang, Noor Huda Daud, Johan E. Deecke, Hanna E. Sidjabat, Sefetogi Ramaologa, Johannes Zuegg, Jason R. Betley, Andrew P. G. Beevers, Richard A. G. Smith, Jason A. Roberts, David L. Paterson, Matthew A. Cooper
Published 2018-01-01

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

by Rink-Jan Lohman, Johan K. Hamidon, Robert C. Reid, Jessica A. Rowley, Mei-Kwan Yau, Maria A. Halili, Daniel S. Nielsen, Junxian Lim, Kai-Chen Wu, Zhixuan Loh, Anh Do, Jacky Y. Suen, Abishek Iyer, David P. Fairlie
Published 2017-08-01

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

by Ting Qi, Yang Wu, Jian Zeng, Futao Zhang, Angli Xue, Longda Jiang, Zhihong Zhu, Kathryn Kemper, Loic Yengo, Zhili Zheng, eQTLGen Consortium, Riccardo E. Marioni, Grant W. Montgomery, Ian J. Deary, Naomi R. Wray, Peter M. Visscher, Allan F. McRae, Jian Yang
Published 2018-06-01

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

by Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang, Kathryn E. Kemper, Zhili Zheng, Loic Yengo, Luke R. Lloyd-Jones, Julia Sidorenko, Yeda Wu, eQTLGen Consortium, Allan F. McRae, Peter M. Visscher, Jian Zeng, Jian Yang
Published 2018-07-01

SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

by Lin Luo, Nilesh J. Bokil, Adam A. Wall, Ronan Kapetanovic, Natalie M. Lansdaal, Faustine Marceline, Belinda J. Burgess, Samuel J. Tong, Zhong Guo, Kirill Alexandrov, Ian L. Ross, Margaret L. Hibbs, Jennifer L. Stow, Matthew J. Sweet
Published 2017-01-01

Widespread signatures of natural selection across human complex traits and functional genomic categories

by Jian Zeng, Angli Xue, Longda Jiang, Luke R. Lloyd-Jones, Yang Wu, Huanwei Wang, Zhili Zheng, Loic Yengo, Kathryn E. Kemper, Michael E. Goddard, Naomi R. Wray, Peter M. Visscher, Jian Yang
Published 2021-02-01

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

by Kerrie-Ann McMahon, Yeping Wu, Yann Gambin, Emma Sierecki, Vikas A. Tillu, Thomas Hall, Nick Martel, Satomi Okano, Shayli Varasteh Moradi, Jayde E. Ruelcke, Charles Ferguson, Alpha S. Yap, Kirill Alexandrov, Michelle M. Hill, Robert G. Parton
Published 2019-07-01

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

by Junqiao Du, Kuok Yap, Lai Yue Chan, Fabian B. H. Rehm, Fong Yang Looi, Aaron G. Poth, Edward K. Gilding, Quentin Kaas, Thomas Durek, David J. Craik
Published 2020-03-01

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

by Yang Wu, Jian Zeng, Futao Zhang, Zhihong Zhu, Ting Qi, Zhili Zheng, Luke R. Lloyd-Jones, Riccardo E. Marioni, Nicholas G. Martin, Grant W. Montgomery, Ian J. Deary, Naomi R. Wray, Peter M. Visscher, Allan F. McRae, Jian Yang
Published 2018-03-01

Global genetic differentiation of complex traits shaped by natural selection in humans

by Jing Guo, Yang Wu, Zhihong Zhu, Zhili Zheng, Maciej Trzaskowski, Jian Zeng, Matthew R. Robinson, Peter M. Visscher, Jian Yang
Published 2018-05-01

Causal associations between risk factors and common diseases inferred from GWAS summary data

by Zhihong Zhu, Zhili Zheng, Futao Zhang, Yang Wu, Maciej Trzaskowski, Robert Maier, Matthew R. Robinson, John J. McGrath, Peter M. Visscher, Naomi R. Wray, Jian Yang
Published 2018-01-01

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

by Joana A. Revez, Tian Lin, Zhen Qiao, Angli Xue, Yan Holtz, Zhihong Zhu, Jian Zeng, Huanwei Wang, Julia Sidorenko, Kathryn E. Kemper, Anna A. E. Vinkhuyzen, Julanne Frater, Darryl Eyles, Thomas H. J. Burne, Brittany Mitchell, Nicholas G. Martin, Gu Zhu, Peter M. Visscher, Jian Yang, Naomi R. Wray, John J. McGrath
Published 2020-04-01

Genome-wide association study of medication-use and associated disease in the UK Biobank

by Yeda Wu, Enda M. Byrne, Zhili Zheng, Kathryn E. Kemper, Loic Yengo, Andrew J. Mallett, Jian Yang, Peter M. Visscher, Naomi R. Wray
Published 2019-04-01

In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation

by Thomas E. Hall, Nick Martel, Nicholas Ariotti, Zherui Xiong, Harriet P. Lo, Charles Ferguson, James Rae, Ye-Wheen Lim, Robert G. Parton
Published 2020-07-01

Dissection of genetic variation and evidence for pleiotropy in male pattern baldness

by Chloe X. Yap, Julia Sidorenko, Yang Wu, Kathryn E. Kemper, Jian Yang, Naomi R. Wray, Matthew R. Robinson, Peter M. Visscher
Published 2018-12-01

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

by Yang Wu, Ting Qi, Huanwei Wang, Futao Zhang, Zhili Zheng, Jennifer E. Phillips-Cremins, Ian J. Deary, Allan F. McRae, Naomi R. Wray, Jian Zeng, Jian Yang
Published 2020-04-01

Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

by Angli Xue, Longda Jiang, Zhihong Zhu, Naomi R. Wray, Peter M. Visscher, Jian Zeng, Jian Yang
Published 2021-01-01

Publisher Correction: Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

by Angli Xue, Longda Jiang, Zhihong Zhu, Naomi R. Wray, Peter M. Visscher, Jian Zeng, Jian Yang
Published 2021-02-01

Improved polygenic prediction by Bayesian multiple regression on summary statistics

by Luke R. Lloyd-Jones, Jian Zeng, Julia Sidorenko, Loïc Yengo, Gerhard Moser, Kathryn E. Kemper, Huanwei Wang, Zhili Zheng, Reedik Magi, Tõnu Esko, Andres Metspalu, Naomi R. Wray, Michael E. Goddard, Jian Yang, Peter M. Visscher
Published 2019-11-01

Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

by Marija Kojic, Monika Gaik, Bence Kiska, Anna Salerno-Kochan, Sarah Hunt, Angelo Tedoldi, Sergey Mureev, Alun Jones, Belinda Whittle, Laura A. Genovesi, Christelle Adolphe, Darren L. Brown, Jennifer L. Stow, Kirill Alexandrov, Pankaj Sah, Sebastian Glatt, Brandon J. Wainwright
Published 2018-08-01