Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance

by Nathan L. Price, Abhishek K. Singh, Noemi Rotllan, Leigh Goedeke, Allison Wing, Alberto Canfrán-Duque, Alberto Diaz-Ruiz, Elisa Araldi, Ángel Baldán, Joao-Paulo Camporez, Yajaira Suárez, Matthew S. Rodeheffer, Gerald I. Shulman, Rafael de Cabo, Carlos Fernández-Hernando
Published 2018-02-01

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

by Barrett L. Updegraff, Xiaorong Zhou, Yabin Guo, Mahesh S. Padanad, Pei-Hsuan Chen, Chendong Yang, Jessica Sudderth, Carla Rodriguez-Tirado, Luc Girard, John D. Minna, Prashant Mishra, Ralph J. DeBerardinis, Kathryn A. O’Donnell
Published 2018-11-01

Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation

by Maria C. Cuitiño, Thierry Pécot, Daokun Sun, Raleigh Kladney, Takayuki Okano-Uchida, Neelam Shinde, Resham Saeed, Antonio J. Perez-Castro, Amy Webb, Tom Liu, Soo In Bae, Linda Clijsters, Nicholas Selner, Vincenzo Coppola, Cynthia Timmers, Michael C. Ostrowski, Michele Pagano, Gustavo Leone
Published 2019-06-01

A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates

by Jennifer R. Keeffe, Koen K.A. Van Rompay, Priscilla C. Olsen, Qiao Wang, Anna Gazumyan, Stephanie A. Azzopardi, Dennis Schaefer-Babajew, Yu E. Lee, Jackson B. Stuart, Anil Singapuri, Jennifer Watanabe, Jodie Usachenko, Amir Ardeshir, Mohsan Saeed, Marianna Agudelo, Thomas Eisenreich, Stylianos Bournazos, Thiago Y. Oliveira, Charles M. Rice, Lark L. Coffey, Margaret R. MacDonald, Pamela J. Bjorkman, Michel C. Nussenzweig, Davide F. Robbiani
Published 2018-11-01

Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation

by Avraham Maimon, Maxim Mogilevsky, Asaf Shilo, Regina Golan-Gerstl, Akram Obiedat, Vered Ben-Hur, Ilana Lebenthal-Loinger, Ilan Stein, Reuven Reich, Jonah Beenstock, Eldar Zehorai, Claus L. Andersen, Kasper Thorsen, Torben F. Ørntoft, Roger J. Davis, Ben Davidson, David Mu, Rotem Karni
Published 2014-04-01

CDG: An Online Server for Detecting Biologically Closest Disease-Causing Genes and its Application to Primary Immunodeficiency

by David Requena, Patrick Maffucci, Patrick Maffucci, Patrick Maffucci, Benedetta Bigio, Lei Shang, Avinash Abhyankar, Bertrand Boisson, Bertrand Boisson, Bertrand Boisson, Peter D. Stenson, David N. Cooper, Charlotte Cunningham-Rundles, Charlotte Cunningham-Rundles, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Laurent Abel, Laurent Abel, Laurent Abel, Yuval Itan, Yuval Itan
Published 2018-06-01

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells

by Judd F. Hultquist, Kathrin Schumann, Jonathan M. Woo, Lara Manganaro, Michael J. McGregor, Jennifer Doudna, Viviana Simon, Nevan J. Krogan, Alexander Marson
Published 2016-10-01

cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

by Shamsideen A. Ojelade, Tom V. Lee, Nikolaos Giagtzoglou, Lei Yu, Berrak Ugur, Yarong Li, Lita Duraine, Zhongyuan Zuo, Vlad Petyuk, Philip L. De Jager, David A. Bennett, Benjamin R. Arenkiel, Hugo J. Bellen, Joshua M. Shulman
Published 2019-08-01

A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV

by Jarrod S. Johnson, Nicholas De Veaux, Alexander W. Rives, Xavier Lahaye, Sasha Y. Lucas, Brieuc P. Perot, Marine Luka, Victor Garcia-Paredes, Lynn M. Amon, Aaron Watters, Ghaith Abdessalem, Alan Aderem, Nicolas Manel, Dan R. Littman, Richard Bonneau, Mickaël M. Ménager
Published 2020-01-01

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease

by Jacqueline M. Ward, Colleen A. Stoyas, Pawel M. Switonski, Farid Ichou, Weiwei Fan, Brett Collins, Christopher E. Wall, Isaac Adanyeguh, Chenchen Niu, Bryce L. Sopher, Chizuru Kinoshita, Richard S. Morrison, Alexandra Durr, Alysson R. Muotri, Ronald M. Evans, Fanny Mochel, Albert R. La Spada
Published 2019-01-01

Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis

by Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Satish K. Nandakumar, Christoph Muus, Jacob C. Ulirsch, Kaitavjeet Chowdhary, Jason D. Buenrostro, Narla Mohandas, Xiuli An, Martin J. Aryee, Aviv Regev, Vijay G. Sankaran
Published 2019-06-01

Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

by Alexandre Caron, Sébastien M. Labbé, Damien Lanfray, Pierre-Gilles Blanchard, Romain Villot, Christian Roy, David M. Sabatini, Denis Richard, Mathieu Laplante
Published 2016-02-01

Insights into the Evolution of Longevity from the Bowhead Whale Genome

by Michael Keane, Jeremy Semeiks, Andrew E. Webb, Yang I. Li, Víctor Quesada, Thomas Craig, Lone Bruhn Madsen, Sipko van Dam, David Brawand, Patrícia I. Marques, Pawel Michalak, Lin Kang, Jong Bhak, Hyung-Soon Yim, Nick V. Grishin, Nynne Hjort Nielsen, Mads Peter Heide-Jørgensen, Elias M. Oziolor, Cole W. Matson, George M. Church, Gary W. Stuart, John C. Patton, J. Craig George, Robert Suydam, Knud Larsen, Carlos López-Otín, Mary J. O’Connell, John W. Bickham, Bo Thomsen, João Pedro de Magalhães
Published 2015-01-01

Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression

by Cody T. Mowery, Jaime M. Reyes, Lucia Cabal-Hierro, Kelly J. Higby, Kristen L. Karlin, Jarey H. Wang, Robert J. Kimmerling, Paloma Cejas, Klothilda Lim, Hubo Li, Takashi Furusawa, Henry W. Long, David Pellman, Bjoern Chapuy, Michael Bustin, Scott R. Manalis, Thomas F. Westbrook, Charles Y. Lin, Andrew A. Lane
Published 2018-11-01

A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility

by Christopher J. Yuskaitis, Brandon M. Jones, Rachel L. Wolfson, Chloe E. Super, Sameer C. Dhamne, Alexander Rotenberg, David M. Sabatini, Mustafa Sahin, Annapurna Poduri
Published 2018-03-01

Structure and Function Studies of the Human Dopamine Receptors

by Kalani, M. Yashar S.
Published 2004

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

by Caleb R Glassman, Leon Su, Sonia S Majri-Morrison, Hauke Winkelmann, Fei Mo, Peng Li, Magdiel Pérez-Cruz, Peggy P Ho, Ievgen Koliesnik, Nadine Nagy, Tereza Hnizdilova, Lora K Picton, Marek Kovar, Paul Bollyky, Lawrence Steinman, Everett Meyer, Jacob Piehler, Warren J Leonard, K Christopher Garcia
Published 2021-05-01

An improved whole life cycle culture protocol for the hydrozoan genetic model Clytia hemisphaerica

by Marion Lechable, Alexandre Jan, Axel Duchene, Julie Uveira, Brandon Weissbourd, Loann Gissat, Sophie Collet, Laurent Gilletta, Sandra Chevalier, Lucas Leclère, Sophie Peron, Carine Barreau, Régis Lasbleiz, Evelyn Houliston, Tsuyoshi Momose
Published 2020-11-01

The Human Cell Atlas

by Aviv Regev, Sarah A Teichmann, Eric S Lander, Ido Amit, Christophe Benoist, Ewan Birney, Bernd Bodenmiller, Peter Campbell, Piero Carninci, Menna Clatworthy, Hans Clevers, Bart Deplancke, Ian Dunham, James Eberwine, Roland Eils, Wolfgang Enard, Andrew Farmer, Lars Fugger, Berthold Göttgens, Nir Hacohen, Muzlifah Haniffa, Martin Hemberg, Seung Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Emma Lundberg, Joakim Lundeberg, Partha Majumder, John C Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai Netea, Garry Nolan, Dana Pe'er, Anthony Phillipakis, Chris P Ponting, Stephen Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua Sanes, Rahul Satija, Ton N Schumacher, Alex Shalek, Ehud Shapiro, Padmanee Sharma, Jay W Shin, Oliver Stegle, Michael Stratton, Michael J T Stubbington, Fabian J Theis, Matthias Uhlen, Alexander van Oudenaarden, Allon Wagner, Fiona Watt, Jonathan Weissman, Barbara Wold, Ramnik Xavier, Nir Yosef, Human Cell Atlas Meeting Participants
Published 2017-12-01

Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions

by Xiangling Meng, Christopher M McGraw, Wei Wang, Junzhan Jing, Szu-Ying Yeh, Li Wang, Joanna Lopez, Amanda M Brown, Tao Lin, Wu Chen, Mingshan Xue, Roy V Sillitoe, Xiaolong Jiang, Huda Y Zoghbi
Published 2019-09-01