Molecular characterization of projection neuron subtypes in the mouse olfactory bulb

by Sara Zeppilli, Tobias Ackels, Robin Attey, Nell Klimpert, Kimberly D Ritola, Stefan Boeing, Anton Crombach, Andreas T Schaefer, Alexander Fleischmann
Published 2021-07-01

Cold-induced hyperphagia requires AgRP neuron activation in mice

by Jennifer D Deem, Chelsea L Faber, Christian Pedersen, Bao Anh Phan, Sarah A Larsen, Kayoko Ogimoto, Jarrell T Nelson, Vincent Damian, Megan A Tran, Richard D Palmiter, Karl J Kaiyala, Jarrad M Scarlett, Michael R Bruchas, Michael W Schwartz, Gregory J Morton
Published 2020-12-01

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

by Vanja Panic, Stephanie Pearson, James Banks, Trevor S Tippetts, Jesse N Velasco-Silva, Sanghoon Lee, Judith Simcox, Gisela Geoghegan, Claire L Bensard, Tyler van Ry, Will L Holland, Scott A Summers, James Cox, Gregory S Ducker, Jared Rutter, Claudio J Villanueva
Published 2020-08-01

Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation

by Emily Ling-Lin Pai, Jin Chen, Siavash Fazel Darbandi, Frances S Cho, Jiapei Chen, Susan Lindtner, Julia S Chu, Jeanne T Paz, Daniel Vogt, Mercedes F Paredes, John LR Rubenstein
Published 2020-05-01

Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis

by Jianxi Zhu, Gehua Zhen, Senbo An, Xiao Wang, Mei Wan, Yusheng Li, Zhiyong Chen, Yun Guan, Xinzhong Dong, Yihe Hu, Xu Cao
Published 2020-05-01

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

by Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li, Jessica YJ Gu, Ulrich Tepass, Avital Adah Rodal, Hugo J Bellen, Joshua M Shulman
Published 2020-04-01

Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

by Lucy LeBlanc, Bum-Kyu Lee, Andy C Yu, Mijeong Kim, Aparna V Kambhampati, Shannon M Dupont, Davide Seruggia, Byoung U Ryu, Stuart H Orkin, Jonghwan Kim
Published 2018-12-01

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

by David Trombley McSwiggen, Anders S Hansen, Sheila S Teves, Hervé Marie-Nelly, Yvonne Hao, Alec Basil Heckert, Kayla K Umemoto, Claire Dugast-Darzacq, Robert Tjian, Xavier Darzacq
Published 2019-04-01

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

by Jennifer L Fribourgh, Ashutosh Srivastava, Colby R Sandate, Alicia K Michael, Peter L Hsu, Christin Rakers, Leslee T Nguyen, Megan R Torgrimson, Gian Carlo G Parico, Sarvind Tripathi, Ning Zheng, Gabriel C Lander, Tsuyoshi Hirota, Florence Tama, Carrie L Partch
Published 2020-02-01

A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria

by John C Whitney, S Brook Peterson, Jungyun Kim, Manuel Pazos, Adrian J Verster, Matthew C Radey, Hemantha D Kulasekara, Mary Q Ching, Nathan P Bullen, Diane Bryant, Young Ah Goo, Michael G Surette, Elhanan Borenstein, Waldemar Vollmer, Joseph D Mougous
Published 2017-07-01

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

by Feng Pan, Thomas S. Wingo, Zhigang Zhao, Rui Gao, Hideki Makishima, Guangbo Qu, Li Lin, Miao Yu, Janice R. Ortega, Jiapeng Wang, Aziz Nazha, Li Chen, Bing Yao, Can Liu, Shi Chen, Ophelia Weeks, Hongyu Ni, Brittany Lynn Phillips, Suming Huang, Jianlong Wang, Chuan He, Guo-Min Li, Tomas Radivoyevitch, Iannis Aifantis, Jaroslaw P. Maciejewski, Feng-Chun Yang, Peng Jin, Mingjiang Xu
Published 2017-04-01

Regulation of X-linked gene expression during early mouse development by Rlim

by Feng Wang, JongDae Shin, Jeremy M Shea, Jun Yu, Ana Bošković, Meg Byron, Xiaochun Zhu, Alex K Shalek, Aviv Regev, Jeanne B Lawrence, Eduardo M Torres, Lihua J Zhu, Oliver J Rando, Ingolf Bach
Published 2016-09-01

In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

by Marco Morselli, William A Pastor, Barbara Montanini, Kevin Nee, Roberto Ferrari, Kai Fu, Giancarlo Bonora, Liudmilla Rubbi, Amander T Clark, Simone Ottonello, Steven E Jacobsen, Matteo Pellegrini
Published 2015-04-01

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

by Wei-Hua Lee, Hitoshi Higuchi, Sakae Ikeda, Erica L Macke, Tetsuya Takimoto, Bikash R Pattnaik, Che Liu, Li-Fang Chu, Sandra M Siepka, Kathleen J Krentz, C Dustin Rubinstein, Robert F Kalejta, James A Thomson, Robert F Mullins, Joseph S Takahashi, Lawrence H Pinto, Akihiro Ikeda
Published 2016-11-01

Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

by Benoit Vanhollebeke, Oliver A Stone, Naguissa Bostaille, Chris Cho, Yulian Zhou, Emilie Maquet, Anne Gauquier, Pauline Cabochette, Shigetomo Fukuhara, Naoki Mochizuki, Jeremy Nathans, Didier YR Stainier
Published 2015-06-01

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

by Ruzbeh Mosadeghi, Kurt M Reichermeier, Martin Winkler, Anne Schreiber, Justin M Reitsma, Yaru Zhang, Florian Stengel, Junyue Cao, Minsoo Kim, Michael J Sweredoski, Sonja Hess, Alexander Leitner, Ruedi Aebersold, Matthias Peter, Raymond J Deshaies, Radoslav I Enchev
Published 2016-03-01

Direct measurement of the mechanical work during translocation by the ribosome

by Tingting Liu, Ariel Kaplan, Lisa Alexander, Shannon Yan, Jin-Der Wen, Laura Lancaster, Charles E Wickersham, Kurt Fredrick, Harry Noller, Ignacio Tinoco Jr, Carlos J Bustamante
Published 2014-08-01

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

by Hari B Kamadurai, Yu Qiu, Alan Deng, Joseph S Harrison, Chris MacDonald, Marcelo Actis, Patrick Rodrigues, Darcie J Miller, Judith Souphron, Steven M Lewis, Igor Kurinov, Naoaki Fujii, Michal Hammel, Robert Piper, Brian Kuhlman, Brenda A Schulman
Published 2013-08-01

Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice

by Christian M Gallardo, Martin Darvas, Mia Oviatt, Chris H Chang, Mateusz Michalik, Timothy F Huddy, Emily E Meyer, Scott A Shuster, Antonio Aguayo, Elizabeth M Hill, Karun Kiani, Jonathan Ikpeazu, Johan S Martinez, Mari Purpura, Andrea N Smit, Danica F Patton, Ralph E Mistlberger, Richard D Palmiter, Andrew D Steele
Published 2014-09-01

PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

by Priyanka Narayan, Grzegorz Sienski, Julia M. Bonner, Yuan-Ta Lin, Jinsoo Seo, Valeriya Baru, Aftabul Haque, Blerta Milo, Leyla A. Akay, Agnese Graziosi, Yelena Freyzon, Dirk Landgraf, William R. Hesse, Julie Valastyan, M. Inmaculada Barrasa, Li-Huei Tsai, Susan Lindquist
Published 2020-10-01