Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma

by Hemant Gujar, Arjun Mehta, Hong-Tao Li, Yvonne C. Tsai, Xiangning Qiu, Daniel J. Weisenberger, Miriam Galvonas Jasiulionis, Gino K. In, Gangning Liang
Published 2021-08-01

Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets

by Giorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni
Published 2021-08-01

We need to bring R0 < 1 to treat cancer too

by Devabhaktuni Srikrishna, Kris Sachsenmeier
Published 2021-07-01

Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage

by Douglas Meyer, Jacob Kames, Haim Bar, Anton A. Komar, Aikaterini Alexaki, Juan Ibla, Ryan C. Hunt, Luis V. Santana-Quintero, Anton Golikov, Michael DiCuccio, Chava Kimchi-Sarfaty
Published 2021-07-01

An implementation science approach to evaluating pathogen whole genome sequencing in public health

by Angeline S. Ferdinand, Margaret Kelaher, Courtney R. Lane, Anders Gonçalves da Silva, Norelle L. Sherry, Susan A. Ballard, Patiyan Andersson, Tuyet Hoang, Justin T. Denholm, Marion Easton, Benjamin P. Howden, Deborah A. Williamson
Published 2021-07-01

An international policy on returning genomic research results

by Anna C. F. Lewis, Bartha Maria Knoppers, Robert C. Green
Published 2021-07-01

DeepProg: an ensemble of deep-learning and machine-learning models for prognosis prediction using multi-omics data

by Olivier B. Poirion, Zheng Jing, Kumardeep Chaudhary, Sijia Huang, Lana X. Garmire
Published 2021-07-01

Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models

by Deepak Vangala, Swetlana Ladigan, Sven T. Liffers, Soha Noseir, Abdelouahid Maghnouj, Tina-Maria Götze, Berlinda Verdoodt, Susanne Klein-Scory, Laura Godfrey, Martina K. Zowada, Mario Huerta, Daniel L. Edelstein, Jaime Martinez de Villarreal, Miriam Marqués, Jörg Kumbrink, Andreas Jung, Tobias Schiergens, Jens Werner, Volker Heinemann, Sebastian Stintzing, Doris Lindoerfer, Ulrich Mansmann, Michael Pohl, Christian Teschendorf, Christiane Bernhardt, Heiner Wolters, Josef Stern, Selami Usta, Richard Viebahn, Jacob Admard, Nicolas Casadei, Stefan Fröhling, Claudia R. Ball, Jens T. Siveke, Hanno Glimm, Andrea Tannapfel, Wolff Schmiegel, Stephan A. Hahn
Published 2021-07-01

Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis

by Marti Bernardo-Faura, Melanie Rinas, Jakob Wirbel, Inna Pertsovskaya, Vicky Pliaka, Dimitris E. Messinis, Gemma Vila, Theodore Sakellaropoulos, Wolfgang Faigle, Pernilla Stridh, Janina R. Behrens, Tomas Olsson, Roland Martin, Friedemann Paul, Leonidas G. Alexopoulos, Pablo Villoslada, Julio Saez-Rodriguez
Published 2021-07-01

Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma

by Clément Meiller, François Montagne, Theo Z. Hirsch, Stefano Caruso, Julien de Wolf, Quentin Bayard, Jean-Baptiste Assié, Léa Meunier, Yuna Blum, Lisa Quetel, Laure Gibault, Ecaterina Pintilie, Cécile Badoual, Sarah Humez, Françoise Galateau-Sallé, Marie-Christine Copin, Eric Letouzé, Arnaud Scherpereel, Jessica Zucman-Rossi, Françoise Le Pimpec-Barthes, Marie-Claude Jaurand, Didier Jean
Published 2021-07-01

Genome-wide sequencing as a first-tier screening test for short tandem repeat expansions

by Indhu-Shree Rajan-Babu, Junran J. Peng, Readman Chiu, IMAGINE Study, CAUSES Study, Chenkai Li, Arezoo Mohajeri, Egor Dolzhenko, Michael A. Eberle, Inanc Birol, Jan M. Friedman
Published 2021-08-01

Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parall...

by Jie Ming, Xinwen Yu, Xiaoqiang Xu, Li Wang, Chao Ding, Zhifeng Wang, Xuan Xie, Sheli Li, Wenjuan Yang, Shu Luo, Qingzhen He, Yafang Du, Zhufang Tian, Xiling Gao, Kaiyan Ma, Yujie Fang, Chen Li, Jiajun Zhao, Xiaokai Wang, Qiuhe Ji
Published 2021-08-01

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

by Jennifer Derrien, Catherine Guérin-Charbonnel, Victor Gaborit, Loïc Campion, Magali Devic, Elise Douillard, Nathalie Roi, Hervé Avet-Loiseau, Olivier Decaux, Thierry Facon, Jan-Philipp Mallm, Roland Eils, Nikhil C. Munshi, Philippe Moreau, Carl Herrmann, Florence Magrangeas, Stéphane Minvielle
Published 2021-08-01

Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors

by Emily F. Davis-Marcisak, Allison A. Fitzgerald, Michael D. Kessler, Ludmila Danilova, Elizabeth M. Jaffee, Neeha Zaidi, Louis M. Weiner, Elana J. Fertig
Published 2021-08-01

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

by David Z. Pan, Zong Miao, Caroline Comenho, Sandhya Rajkumar, Amogha Koka, Seung Hyuk T. Lee, Marcus Alvarez, Dorota Kaminska, Arthur Ko, Janet S. Sinsheimer, Karen L. Mohlke, Nicholas Mancuso, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Maria Teresa Tusié-Luna, Carlos Aguilar-Salinas, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Markku Laakso, Kristina M. Garske, Päivi Pajukanta
Published 2021-08-01

Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2

by Juan Ángel Patiño-Galindo, Ioan Filip, Ratul Chowdhury, Costas D. Maranas, Peter K. Sorger, Mohammed AlQuraishi, Raul Rabadan
Published 2021-08-01

A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank

by Guiying Dong, Jianfeng Feng, Fengzhu Sun, Jingqi Chen, Xing-Ming Zhao
Published 2021-07-01

High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

by Siel Olbrecht, Pieter Busschaert, Junbin Qian, Adriaan Vanderstichele, Liselore Loverix, Toon Van Gorp, Els Van Nieuwenhuysen, Sileny Han, Annick Van den Broeck, An Coosemans, Anne-Sophie Van Rompuy, Diether Lambrechts, Ignace Vergote
Published 2021-07-01

The host transcriptional response to Candidemia is dominated by neutrophil activation and heme biosynthesis and supports novel diagnostic approaches

by Julie M. Steinbrink, Rachel A. Myers, Kaiyuan Hua, Melissa D. Johnson, Jessica L. Seidelman, Ephraim L. Tsalik, Ricardo Henao, Geoffrey S. Ginsburg, Christopher W. Woods, Barbara D. Alexander, Micah T. McClain
Published 2021-07-01

Correction to: Family history assessment significantly enhances delivery of precision medicine in the genomics era

by Yasmin Bylstra, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R. Ryanne Wu, Jing Xian Teo, Sonia Davila, Jyn Ling Kuan, Sock Hoai Chan, Nicolas Bertin, Cheng Xi Yang, Steve Rozen, Bin Tean Teh, Khung Keong Yeo, Stuart Alexander Cook, Saumya Shekhar Jamuar, Geoffrey S. Ginsburg, Lori A. Orlando, Patrick Tan
Published 2021-07-01