Nonclinical Development of BCG Replacement Vaccine Candidates

by Bernd Eisele, Martin Gengenbacher, Reginald Kidd, David McCown, Sheldon Morris, Steven Derrick, David Hokey, Dominick Laddy, Rosemary Chang, Megan Fitzpatrick, Leander Grode, Kamalakannan Velmurugan, Stefan H.E. Kaufmann, John Fulkerson, Michael J. Brennan
Published 2013-04-01

Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ΔureC::hly Improves Protection against Tuberculosis

by Martin Gengenbacher, Natalie Nieuwenhuizen, Alexis Vogelzang, Haipeng Liu, Peggy Kaiser, Stefanie Schuerer, Doris Lazar, Ina Wagner, Hans-Joachim Mollenkopf, Stefan H. E. Kaufmann
Published 2016-05-01

Pyrazinamide triggers degradation of its target aspartate decarboxylase

by Pooja Gopal, Jickky Palmae Sarathy, Michelle Yee, Priya Ragunathan, Joon Shin, Shashi Bhushan, Junhao Zhu, Tatos Akopian, Olga Kandror, Teck Kwang Lim, Martin Gengenbacher, Qingsong Lin, Eric J. Rubin, Gerhard Grüber, Thomas Dick
Published 2020-04-01

The tuberculosis vaccine candidate Bacillus Calmette-Guérin ΔureC::hly coexpressing human interleukin-7 or -18 enhances antigen-specific T cell responses in mice.

by Martin Rao, Alexis Vogelzang, Peggy Kaiser, Stefanie Schuerer, Stefan H E Kaufmann, Martin Gengenbacher
Published 2013-01-01

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

by Martin Teichert, Laura Milde, Annegret Holm, Laura Stanicek, Nicolas Gengenbacher, Soniya Savant, Tina Ruckdeschel, Zulfiyya Hasanov, Kshitij Srivastava, Junhao Hu, Stella Hertel, Arne Bartol, Katharina Schlereth, Hellmut G. Augustin
Published 2017-07-01

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis

by Dereje Abate Negatu, Yoshiyuki Yamada, Yu Xi, Mei Lin Go, Matthew Zimmerman, Uday Ganapathy, Véronique Dartois, Martin Gengenbacher, Thomas Dick
Published 2019-03-01

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

by Martin Gengenbacher, Maria A. Duque-Correa, Peggy Kaiser, Stefanie Schuerer, Doris Lazar, Ulrike Zedler, Stephen T. Reece, Amit Nayyar, Stewart T. Cole, Vadim Makarov, Clifton E. Barry III, Véronique Dartois, Stefan H. E. Kaufmann
Published 2017-08-01

Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens

by Frida Arrey, Delia Löwe, Stefanie Kuhlmann, Peggy Kaiser, Pedro Moura-Alves, Gopinath Krishnamoorthy, Laura Lozza, Jeroen Maertzdorf, Tatsiana Skrahina, Alena Skrahina, Martin Gengenbacher, Geraldine Nouailles, Stefan H. E. Kaufmann
Published 2019-01-01

Proteomic Phosphosite Analysis Identified Crucial NPM-ALK-Mediated NIPA Serine and Threonine Residues

by Anina Gengenbacher, Alina Müller-Rudorf, Teresa Poggio, Linda Gräßel, Veronica I. Dumit, Stefanie Kreutmair, Lena J. Lippert, Justus Duyster, Anna L. Illert
Published 2019-08-01

Preclinical validation of a novel metastasis‐inhibiting Tie1 function‐blocking antibody

by Mahak Singhal, Nicolas Gengenbacher, Silvia La Porta, Stephanie Gehrs, Jingjing Shi, Miki Kamiyama, Diane M Bodenmiller, Anthony Fischl, Benjamin Schieb, Eva Besemfelder, Sudhakar Chintharlapalli, Hellmut G Augustin
Published 2020-06-01

Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression

by Christopher Groth, Ludovica Arpinati, Merav E. Shaul, Nina Winkler, Klara Diester, Nicolas Gengenbacher, Rebekka Weber, Ihor Arkhypov, Samantha Lasser, Vera Petrova, Hellmut G. Augustin, Peter Altevogt, Jochen Utikal, Zvi G. Fridlender, Viktor Umansky
Published 2021-02-01

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption

by Annanya Shetty, Annanya Shetty, Zhujun Xu, Umayal Lakshmanan, Jeffrey Hill, Meng Ling Choong, Shu-Sin Chng, Shu-Sin Chng, Yoshiyuki Yamada, Anders Poulsen, Thomas Dick, Thomas Dick, Martin Gengenbacher
Published 2018-12-01

The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs

by Huan Chen, Samuel A. Nyantakyi, Ming Li, Pooja Gopal, Dinah B. Aziz, Tianming Yang, Wilfried Moreira, Martin Gengenbacher, Thomas Dick, Mei L. Go
Published 2018-07-01