miR-221-3p Aged 1 Airway Remodeling 1 Apoptosis 1 Article 1 Bronchi 1 Case-Control Studies 1 Cell Line 1 Cell Proliferation 1 Cell Survival 1 Cytokines 1 Epithelial Cells 1 Extracellular vesicle 1 Female 1 Fibrosis 1 Genetic Association Studies 1 Genetic Predisposition to Disease 1 HBEC cell line (bronchial epithelium) 1 Humans 1 Inflammation 1 Ligamentum flavum hypertrophy 1 MIRN221 microRNA, human 1 MIRN92 microRNA, human 1 Male 1 MicroRNAs 1 Middle Aged 1 Pulmonary Disease, Chronic Obstructive 1 RNA blood level 1 Smoking 1 Umbilical cord mesenchymal stromal cells 1