algorithm 2 article 2 metabolic engineering Algorithms 1 Biological systems 1 Cell culture 1 Cellular metabolism 1 Complex networks 1 Escherichia coli 1 Flowcharting 1 Kinetic model 1 Kinetic modeling 1 Kinetic parameters 1 Kinetic theory 1 Kinetics 1 Metabolic Engineering 1 Metabolic Networks and Pathways 1 Metabolic control analysis 1 Metabolic engineering 1 Metabolic flux distribution 1 Metabolic networks 1 Metabolic reconstruction 1 Metabolism 1 Model complexity 1 Model reduction 1 Models, Biological 1 Network complexity 1 Sensitivity characteristics 1 Sensitivity coefficient 1 Stoichiometric models 1