Article 1 Broad spectrum resistance 1 CRISPR-CAS9 system 1 Co-evolution 1 Cucumber mosaic virus 1 Nicotiana tabacum 1 Plant immunity 1 RNA interference 1 Tobamovirus 1 Tomato bushy stunt virus 1 Tomato spotted wilt virus 1 Virus adaptation 1 Virus vectors 1 antiviral activity 1 argonaute protein 1 crop protection cucumber 1 disease control 1 disease resistance 1 double-stranded DNA virus 1 gene control 1 gene expression 1 gene silencing 1 genetic engineering 1 genetic variability 1 host range 1 host resistance 1 innate immunity 1 insect vector 1 nonhuman 1