copolymer Article 4 controlled study 3 drug delivery system 3 Administration, Oral 2 Animals 2 Humans 2 MTT assay 2 Polymers 2 differential scanning calorimetry 2 drug absorption 2 drug release 2 fluorescence microscopy 2 glucose 2 in vitro study 2 nonhuman 2 oral drug administration 2 physical chemistry 2 priority journal 2 process optimization 2 proton nuclear magnetic resonance 2 synthesis 2 unclassified drug 2 3 hydroxybutyric acid 1 3-Hydroxybutyric Acid 1 4 hydroxybutyric acid 1 4-hydroxybutyrate 1 Alginates 1 Amphiphilic compound 1 BT-474 cell line 1