area under the curve human 96 Article 91 controlled study 78 male 73 Humans 68 female 68 adult 62 receiver operating characteristic 61 major clinical study 57 Female 44 Male 43 aged 37 middle aged 37 sensitivity and specificity 37 Middle Aged 33 diagnostic test accuracy study 29 Aged 23 Adult 21 blood 20 prediction 20 pathology 19 predictive value 19 Area Under Curve 18 ROC Curve 17 biological marker 17 comparative study 17 genetics 17 procedures 17 unclassified drug 17