alkaptonuria nitisinone 3 Article 2 human 2 tyrosine 2 tyrosinemia 2 Alkaptonuria 1 BDI-II 1 Beck Depression Inventory 1 Late-stage clinical development 1 Public funding 1 Research funding 1 Return on investment 1 WAIS-IV 1 Wechsler adult intelligence scale 1 adult 1 aged 1 antidepressant agent 1 cataract 1 chronic hepatitis C 1 clinical development plan 1 cognition 1 cognitive functioning 1 controlled study 1 depression 1 dietary intake 1 disease exacerbation 1 drug cost 1 drug marketing 1 female 1