Article 1 Breast Neoplasms 1 Cancer 1 Female 1 Genome-Wide Association Study 1 Germ Cells 1 Humans 1 Male 1 Mutation 1 Mutational signature 1 Polygenic risk score 1 Risk Factors 1 Single-base substitution signature Somatic mutation 1 biological trait 1 breast cancer 1 breast tumor 1 cancer risk 1 estrogen receptor positive breast cancer 1 female 1 genetic association 1 genetic risk 1 genetic risk score 1 genetic variation 1 genetics 1 genome-wide association study 1 germ cell 1 human 1 major clinical study 1 male 1