Pi3K/Akt signaling nonhuman 7 Article 6 animal experiment 6 controlled study 6 metabolism 5 mouse 5 Animals 4 Humans 4 animal 4 animal cell 4 animal model 4 female 4 gene expression 4 genetics 4 human 4 protein expression 4 Female 3 Mice 3 animal tissue 3 gene 3 phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase 3 signal transduction 3 MCF-7 Cells 2 MCF-7 cell line 2 Myocardium 2 Nicotine 2 Signal Transduction 2 Western blotting 2 alpha tocotrienol 2