Association reactions 1 Computation theory 1 Computational bottlenecks 1 Computational tractability 1 Epistasis, Genetic 1 Genome-Wide Association Study 1 Genome-wide association studies 1 Genotype 1 Humans 1 Information theoretic measure 1 Information theory 1 Large dataset 1 Large-scale datasets 1 Multi-locus GWAS 1 Multivariable interactions Permutation testing 1 Permutation tests 1 Phenotype 1 Polymorphism, Single Nucleotide 1 Significance analysis 1 adult 1 article 1 cell proliferation 1 epistasis 1 gene interaction 1 genome-wide association study 1 genotype 1 human 1 information science 1 phenotype 1