Algorithms 1 Alignment 1 Computational Biology 1 Computationally efficient 1 Conservation 1 Conservation biology 1 Conservation scores 1 Evolutionary conservations Frequency estimation 1 Genetic sequence 1 Homologous sequences 1 Phylogenetic approach 1 Phylogenetics 1 Phylogeny 1 Protein profile 1 Proteins 1 Sequence Alignment 1 Sequence alignments 1 Sequence weighting 1 Sequence weights 1 algorithm 1 article 1 biology 1 conservation biology 1 genetic conservation 1 phylogeny 1 position weight matrix 1 protein family 1 protein fingerprinting 1 sequence alignment 1