Computational bottlenecks Humans 2 article 2 human 2 Algorithms 1 Alignment 1 Amino Acid Sequence 1 Association reactions 1 Coevolution 1 Computation theory 1 Computational tractability 1 Couplings 1 Direct coupling analysis 1 Epistasis, Genetic 1 Functional annotation 1 Genome-Wide Association Study 1 Genome-wide association studies 1 Genotype 1 Hidden Markov models 1 Homology 1 Information theoretic measure 1 Information theory 1 Integer linear programming 1 Integer linear programming formulation 1 Integer programming 1 Large dataset 1 Large-scale datasets 1 Multi-locus GWAS 1 Multivariable interactions 1 Optimal alignments 1