Activation analysis 1 Amino Acid Substitution 1 Amino acid sequence 1 Amino acids 1 Animals 1 C-terminal sequences 1 Calcium 1 Calcium Imaging 1 Calcium Influx Cell death 1 Channel Gating 1 Current-voltage relationship 1 HEK293 Cells 1 Humans 1 Ion Channel Gating 1 Ion Channels 1 Mice 1 Models, Molecular 1 Mutation, Missense 1 Non-selective cation channels 1 Open conformation 1 Patch Clamp 1 Peptide Mapping 1 Phosphoinositides 1 Protein Structure, Secondary 1 Protein Structure, Tertiary 1 Proteins 1 Rats 1 Signal Transduction 1 Signaling cascades 1