3 hydroxy 1 (2 hydroxy 4 methoxyphenyl) 3 phenylprop 2 en 1 one 1 3 hydroxy 1 (2 hydroxyphenyl) 3 phenylprop 2 en 1 one 1 3 hydroxy 1 (2 hydroxyphenyl) 5 phenylpenta 2,4 dien 1 one 1 Article 1 COX-2 mRNA expression Dynamic simulation 1 IC50 1 MAPK phosphorylation 1 MAPK signaling 1 Molecular 1 Prostaglandin E2 1 RAW 264.7 cell line 1 U-937 cell line 1 Unsymmetrical dicarbonyl curcumin derivatives 1 [2 hydroxy 3 (4 methoxybenzylidene)cyclohex 1 en 1 yl](phenyl)methanone 1 [3 (2,3 dimethoxybenzylidene) 2 hydroxycyclohex 1 en 1 yl](phenyl)methanone 1 antiinflammatory activity 1 antiinflammatory agent 1 controlled study 1 curcumin 1 cyclooxygenase 1 1 cyclooxygenase 2 1 drug absorption 1 drug distribution 1 drug elimination 1 drug metabolism 1 drug synthesis 1 enzyme inhibition 1 enzyme phosphorylation 1 gamma interferon 1