Modulation of cellular glucose metabolism in human HepG2 cells by combinations of structurally related flavonoids

Modulation of cellular glucose metabolism in human HepG2 cells by combinations of structurally related flavonoids

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Scope: Insulin-regulated glucose metabolism in cells is critical for proper metabolic functioning, and insulin resistance leads to type 2 diabetes. We performed a human study to assess the availability of structurally related dietary flavonols and tested their ability to affect cellular glucose upta...

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Bibliographic Details
Main Authors: Jailani, F (Author), Kerimi, A (Author), Williamson, G (Author)
Format: Article
Language:English
Published: 2015
Subjects:
ABSORPTION
GALANGIN
GLUT1
HEPATOCYTES
HUMAN PLASMA
INSULIN
INVOLVEMENT
POLYPHENOLS
QUERCETIN
TRANSPORTER
Online Access:View Fulltext in Publisher
Description
Summary:Scope: Insulin-regulated glucose metabolism in cells is critical for proper metabolic functioning, and insulin resistance leads to type 2 diabetes. We performed a human study to assess the availability of structurally related dietary flavonols and tested their ability to affect cellular glucose uptake, metabolism, and glucose transporter gene expression in a liver HepG2 cell model.
DOI:10.1002/mnfr.201400850

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