ENHANCED INFLAMMATION IN SUBGROUPS OF METABOLIC SYNDROME IRRESPECTIVE OF GLYCAEMIC STATUS

• Main Authors: Ismai, Z (Author), Nasir, NM (Author), Nawawi, HM (Author), Osman, MT (Author), Rahman, T (Author), Ramli, AS (Author), Razak, SA (Author), Saimin, H (Author)
• Format: Article
• Language: English
• Published: 2017
• Subjects: ADIPONECTIN; CARDIOVASCULAR-DISEASE; CIRCULATING ADHESION MOLECULES; COMPLICATIONS; C-REACTIVE PROTEIN; DIABETIC-NEPHROPATHY; endothelial activation; glycaemic status; inflammation; INSULIN-RESISTANCE; MARKERS; metabolic syndrome; MORTALITY; RISK
• Online Access: View Fulltext in Publisher

 The objectives of this study were toinvestigate the inflammation and endothelial activation biomarkers in subjects with metabolic syndrome (MS)subgroups irrespective of glycaemic status. Subjects (n=319) were categorized into MS subgroups [diabetes mellitus (MSDM), impaired fastig glucose (MSIFG) and normoglycemia (MSNG)] and normal controls (NC). Inflammatory biomarkers (high-sensitivity C-reactive protein and interleukin-6) and endothelial activation (soluble intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin) were measured and compared between the groups.MS subjects had significant increase in all biomarkers compared to NC subjects. Glycaemic status in MS subgroups did not show any association with the quartiles of all biomarkers, except for interleukin-6. This may partially explain their increased coronary risk.