|
|
|
|
| LEADER |
01541nam a2200205Ia 4500 |
| 001 |
10.4238-2014.February.19.9 |
| 008 |
220127s2014 CNT 000 0 und d |
| 020 |
|
|
|a 1676-5680
|
| 245 |
1 |
0 |
|a A novel rare copy number variant of the ABCF1 gene identified among dengue fever patients from Peninsular Malaysia
|
| 490 |
1 |
0 |
|t GENETICS AND MOLECULAR RESEARCH
|
| 856 |
|
|
|z View Fulltext in Publisher
|u https://doi.org/10.4238/2014.February.19.9
|
| 520 |
3 |
|
|a Copy number variation (CNV) is a form of genetic variation in addition to single nucleotide polymorphisms. The significance of CNV in the manifestation of a number of diseases is only recently receiving considerable attention. We genotyped 163 dengue patients from Peninsular Malaysia for genes possibly linked to dengue infection using quantitative real-time PCR. Here, we report a serendipitous discovery of a novel rare CNV of the ABCF1 gene among the dengue patients. Among these patients, two had a gain of 1 copy (CN = 3) and one had lost 1 copy (CN = 1), indicating that a rare CNV of the ABCF1 gene was detected among dengue patients from Peninsular Malaysia. Although the gene is suspected to regulate inflammatory responses and pathogen-induced cytokine storm, its relevance to dengue requires further investigation.
|
| 700 |
1 |
0 |
|a AbuBakar, S
|e author
|
| 700 |
1 |
0 |
|a Hanim, SR
|e author
|
| 700 |
1 |
0 |
|a Hoh, BP
|e author
|
| 700 |
1 |
0 |
|a Khairudin, NYN
|e author
|
| 700 |
1 |
0 |
|a Mahiran, M
|e author
|
| 700 |
1 |
0 |
|a Sam, SS
|e author
|
| 700 |
1 |
0 |
|a Umi, SH
|e author
|
| 773 |
1 |
0 |
|t GENETICS AND MOLECULAR RESEARCH
|
