Smart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation

Smart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation

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Artemether (ARTM) is a very effective antimalarial drug with poor solubility and consequently low bioavailability. Smart nanocrystals of ARTM with particle size of 161 +/- 1.5 nm and polydispersity index of 0.172 +/- 0.01 were produced in,<1 hour using a wet milling technology, Dena (R) DM-100. T...

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Bibliographic Details
Main Authors: AbdEl-Salam, NM (Author), Assi, KH (Author), de Matas, M (Author), Hussain, Z (Author), Isreb, M (Author), Khan, S (Author), Minhas, MU (Author), Shah, SMH (Author), Shah, SMM (Author), Ullah, F (Author)
Format: Article
Language:English
Published: 2016
Subjects:
antimalarial activity
artemether
BIOAVAILABILITY
DELIVERY
FORMULATION
in vitro dissolution
MALARIA PARASITES
milling
NANOPARTICLES
nanosuspension
NANOSUSPENSIONS
PARTICLE-SIZE
smart nanocrystals
SOLID DISPERSIONS
SOLUBILITY
WATER-SOLUBLE DRUGS
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