ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND ANTIPYRETIC EFFECTS OF SOLANUM NIGRUM AQUEOUS EXTRACT IN ANIMAL MODELS

• Main Authors: Aris, A (Author), Kumar, CH (Author), Morsid, NA (Author), Pojan, NHM (Author), Sulaiman, MR (Author), Zainal, H (Author), Zakaria, ZA (Author)
• Format: Article
• Language: English
• Series: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
• Online Access: View Fulltext in Publisher
• ISBN: 0379-0355; 2013-0155
• ISSN: 2013-0155
• DOI: 10.1358/mf.2009.31.2.1353876

The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of the aqueous extract of Solanum nigrum leaves using various animal models. The extract, at concentrations of 10, 50 and 100%, was prepared by soaking (1:20; w/v) air-dried powdered leaves (20 g) in distilled water (dH2O) for 72 h. The extract Solutions were administered subcutaneously ill mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (P < 0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Overall, these activities occurred in a concentration-dependent manner, except for the 50% concentration of the extract, which was not effective in the abdominal constriction test. In conclusion, the present Study demonstrated that S. nigrum leaves possessed antinociceptive, anti-inflammatory and antipyretic effects and thus supported traditional claims of its medicinal uses.