4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation

4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation

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Background: Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have be...

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Bibliographic Details
Main Authors: Lim, SM (Author), Mani, V (Author), Narasimhan, B (Author), Ramasamy, K (Author), Shah, SAA (Author), Tahlan, S (Author)
Format: Article
Language:English
Published: 2019
Subjects:
2-Mercaptobenzimidazole derivatives
Antibacterial
ANTIBACTERIAL
Anticancer
Antifungal
ANTIMICROBIAL ACTIVITY
BENZIMIDAZOLE DERIVATIVES
p-Amino benzoic acid
QSAR
Online Access:View Fulltext in Publisher
Description
Summary:Background: Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have been broadly examined for their anticancer potential, so, we hereby report the design, synthesis and biological studies (i.e. antimicrobial and anticancer studies) of 2MBI derivatives.
DOI:10.1186/s13065-019-0533-7

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