Eurycoma longifolia, a promising suppressor of RANKL-induced differentiation and activation of osteoclasts: An in vitro mechanistic evaluation

Eurycoma longifolia, a promising suppressor of RANKL-induced differentiation and activation of osteoclasts: An in vitro mechanistic evaluation

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Background: Eurycoma longifolia (E. longifolia) has gained remarkable recognition due to its promising efficacy of stimulating bone formation in androgen-deficient osteoporosis. Numerous in vivo studies have explored the effects of E. longifolia on osteoporosis; however, the in vitro cellular mechan...

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Bibliographic Details
Main Authors: Hussain, Z (Author), Mohamed, IN (Author), Shuid, AN (Author), Thu, HE (Author)
Format: Article
Language:English
Published: 2019
Subjects:
Bone resorption
BONE-RESORPTION
CATHEPSIN-K
CELLS
Eurycoma longifolia
EXPRESSION
KAPPA-B LIGAND
MATRIX-METALLOPROTEINASE-9
Molecular mechanism
Osteoclastogenesis
Osteoclasts
Osteoporosis
OSTEOPOROSIS
QUASSINOIDS
RAW264.7
RECEPTOR ACTIVATOR
Online Access:View Fulltext in Publisher
Description
Summary:Background: Eurycoma longifolia (E. longifolia) has gained remarkable recognition due to its promising efficacy of stimulating bone formation in androgen-deficient osteoporosis. Numerous in vivo studies have explored the effects of E. longifolia on osteoporosis; however, the in vitro cellular mechanism was not discovered yet.
DOI:10.1016/j.jaim.2017.07.014

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