Molecular mechanism for the control of eukaryotic elongation factor 2 kinase by pH: role in cancer cell survival

Acidification of the extracellular and/or intracellular environment is involved in many aspects of cell physiology and pathology. Eukaryotic elongation factor 2 kinase (eEF2K) is a Ca(2+)/calmodulin-dependent kinase that regulates translation elongation by phosphorylating and inhibiting eEF2. Here w...

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Bibliographic Details
Main Authors: Xie, Jianling (Author), Mikolajek, Halina (Author), Pigott, Craig R. (Author), Hooper, Kelly J. (Author), Mellows, Toby (Author), Moore, Claire E. (Author), Mohammed, Hafeez (Author), Werner, Jörn M. (Author), Thomas, Gareth J. (Author), Proud, Christopher G. (Author)
Format: Article
Language:English
Published: 2015-05.
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