Synthesis and evaluation of a (3R, 6S, 9S)-2-oxo-1-azabicyclo[4.3.0]nonane scaffold as a mimic of Xaa-transPro in poly-L-proline type II helix conformation

Synthesis and evaluation of a (3R, 6S, 9S)-2-oxo-1-azabicyclo[4.3.0]nonane scaffold as a mimic of Xaa-transPro in poly-L-proline type II helix conformation

We describe the development of a small-molecule mimic of Xaa-trans-Pro dipeptide in poly-L-proline type II helix conformation, based upon a (3R,6S,9S)-2-oxo-1-azabicyclo[4.3.0]nonane core structure. Stereoselective synthesis of the mimic from L-pyroglutamic acid is achieved in twelve linear steps an...

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Main Authors:	Aillard, Boris (Author), Kilburn, Jeremy D. (Author), Blaydes, Jeremy P. (Author), Tizzard, Graham J. (Author), Findlow, I.Stuart C. (Author), Werner, Jörn M. (Author), Bloodworth, Sally (Author)
Format:	Article
Language:	English
Published:	2015-03-10.
Subjects:	Article
Online Access:	Get fulltext

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