Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

In human and rat vascular tissue in vitro, hypoxic nitrite-mediated vasodilatation involves ALDH2. In patients with heart failure in vivo the role of this enzyme in nitrite bioactivation is at most modest, suggesting the involvement of other more important mechanisms.

Bibliographic Details
Main Authors: Arif, Sayqa (Author), Borgognone, Alessandra (Author), Lin, Erica Lai-Sze (Author), O'Sullivan, Aine G. (Author), Sharma, Vishal (Author), Drury, Nigel E. (Author), Menon, Ashvini (Author), Nightingale, Peter (Author), Mascaro, Jorge (Author), Bonser, Robert S. (Author), Horowitz, John D. (Author), Feelisch, Martin (Author), Frenneaux, Michael P. (Author), Madhani, Melanie (Author)
Format: Article
Language:English
Published: 2015-03-05.
Subjects:
Article
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