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01420 am a22001573u 4500 |
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363681 |
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|a Saha, Shimul C.
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|a Thei, Federico
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|a de Planque, Maurits R.R.
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|a Morgan, Hywel
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|a Scaleable micro-cavity bilayer lipid membrane array for parallel ion channel recording
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|c 2014-08.
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|z Get fulltext
|u https://eprints.soton.ac.uk/363681/1/Saha_SensorsActuatorsB_2014.pdf
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|a A compact, scalable and high-throughput bilayer ion channel recording platform capable of simultaneous data acquisition from multiple bilayers is presented. Microfluidic chips house micro-cavities over which bilayers are made; each connected to a custom-made compact electronic readout circuit based on ASICs (Application-Specific Integrated Circuits). The micro-cavities are fabricated using a simple dry-film resist process on a glass wafer. Single 15 mm × 15 mm glass chips contain four separately addressable bilayers, each with integrated Ag/AgCl electrodes. The number of bilayers is scaled by increasing the number of ASICs and four-cavity chips. Each chip can be cleaned and re-used many times and the cavity-suspended lipid bilayers are stable for up to 10 days. System performance is demonstrated with simultaneous electrical recordings of the ion channels gramicidin A and alpha-hemolysin in multiple bilayers.
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