A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin ? C as a compatible prognostic marker in human solid tumors.

• Main Authors: Schmidt, Marcus (Author), Hellwig, Birte (Author), Hammad, Seddik (Author), Othman, Amnah (Author), Lohr, Miriam (Author), Chen, Zonglin (Author), Boehm, Daniel (Author), Gebhard, Susanne (Author), Petry, Ilka (Author), Lebrecht, Antje (Author), Cadenas, Cristina (Author), Marchan, Rosemarie (Author), Stewart, Joanna D (Author), Solbach, Christine (Author), Holmberg, Lars (Author), Edlund, Karolina (Author), Kultima, Hanna Göransson (Author), Rody, Achim (Author), Berglund, Anders (Author), Lambe, Mats (Author), Isaksson, Anders (Author), Botling, Johan (Author), Karn, Thomas (Author), Müller, Volkmar (Author), Gerhold-Ay, Aslihan (Author), Cotarelo, Christina (Author), Sebastian, Martin (Author), Kronenwett, Ralf (Author), Bojar, Hans (Author), Lehr, Hans-Anton (Author), Sahin, Ugur (Author), Koelbl, Heinz (Author), Gehrmann, Mathias (Author), Micke, Patrick (Author), Rahnenführer, Jörg (Author), Hengstler, Jan G (Author)
• Format: Article
• Language: English
• Published: 2012-05-01.
• Subjects: Article
• Online Access: Get fulltext

Our findings provide IGKC as a novel diagnostic marker for risk stratification in human cancer and support concepts to exploit the humoral immune response for anticancer therapy. It could be validated in several independent cohorts and carried out similarly well in RNA from fresh frozen as well as from paraffin tissue and on protein level by immunostaining.