Chemically modified siRNA: tools and applications

Chemically modified siRNA: tools and applications

Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, wi...

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Bibliographic Details
Main Authors: Watts, Jonathan K. (Author), Deleavey, Glen F. (Author), Damha, Masad J. (Author)
Format: Article
Language:English
Published: 2008-10.
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Summary:Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, with a focus on specificity (elimination of immune effects and hybridization-dependent off-target effects) and delivery. We also discuss improvement of nuclease stability and potency.

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