Cell-produced ?-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

Cell-produced ?-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

?-Synuclein is central in Parkinson's disease pathogenesis. Although initially ?-synuclein was considered a purely intracellular protein, recent data suggest that it can be detected in the plasma and CSF of humans and in the culture media of neuronal cells. To address a role of secreted ?-synuc...

Full description

Bibliographic Details
Main Authors: Emmanouilidou, Evangelia (Author), Melachroinou, Katerina (Author), Roumeliotis, Theodoros (Author), Garbis, Spiros D. (Author), Ntzouni, Maria (Author), Margaritis, Lukas H. (Author), Stefanis, Leonidas (Author), Vekrellis, Kostas (Author)
Format: Article
Language:English
Published: 2010-05-19.
Subjects:
Article
Online Access:Get fulltext

Similar Items

Similar Items