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01519 am a22001813u 4500 |
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26159 |
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|a dc
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|a Zhang, Junlong
|e author
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|a Holt, Richard I.G.
|e author
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|a Wild, Sarah H.
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|a Poole, Ruth B.
|e author
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|a Holt, Helen
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|a Byrne, Christopher D.
|e author
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|a Letters: observations. Plasma adiponectin concentrations are independently predicted by fat insulin sensitivity in women and by muscle insulin sensitivity in men
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|c 2005.
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|z Get fulltext
|u https://eprints.soton.ac.uk/26159/1/755.pdf
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|a Adiponectin is an abundant plasma protein, mainly secreted by adipocytes and closely linked to insulin sensitivity (1-4). Plasma adiponectin independently correlates with insulin sensitivity (5). Since women have greater plasma adiponectin levels than men (5-7), we determined sex-specific differences in associations between plasma adiponectin and tissue-specific insulin sensitivity in skeletal muscle, liver, and fat. Plasma adiponectin concentrations were measured (intra-assay coefficient of variation <4%) in 28 men and 28 women (6 men and 6 women had impaired glucose tolerance according to World Health Organization criteria). Insulin sensitivity in skeletal muscle, liver, and fat was determined by insulin-mediated whole-body glucose disposal (M values), suppression of hepatic glucose output evaluated during a hyperinsulinemic-euglycemic clamp, and suppression of free fatty acid (FFA).
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