Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesus
The cells within the intact islet of Langerhans function as a metabolic syncytium, secreting insulin in a coordinated and oscillatory manner in response to external fuel. With increased glucose, the oscillatory amplitude is enhanced, leading to the hypothesis that cells within the islet are secretin...
Main Authors: | Katzman, S.M (Author), Messerli, M.A (Author), Grossman, A. (Author), Harel, T. (Author), Barry, D.T (Author), Smith, P.J.S (Author), Chenault, V.M (Author), Shirihai, O.S (Author) |
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Format: | Article |
Language: | English |
Published: |
2004-12.
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Subjects: | |
Online Access: | Get fulltext |
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