HDMX-L is expressed from a functional P53-responsive promoter in the first intron of the HDMX gene, and participates in an auto-regulatory feedback loop to control P53 activity.

HDMX-L is expressed from a functional P53-responsive promoter in the first intron of the HDMX gene, and participates in an auto-regulatory feedback loop to control P53 activity.

The p53 regulatory network is critically involved in preventing the initiation of cancer. In unstressed cells p53 is maintained at low levels and is largely inactive, mainly through the action of its two essential negative regulators, HDM2 and HDMX. p53 abundance and activity are upregulated in resp...

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Main Authors: Phillips, Anna (Author), Teunisse, Amina (Author), Lam, Suzanne (Author), Lodder, Kirsten (Author), Darley, Matthew (Author), Emaduddin, Muhammad (Author), Wolf, Anja (Author), Richter, Julia (Author), de Lange, Job (Author), Verlaan-de Vries, Matty (Author), Lenos, Kristiaan (Author), Boehnke, Anja (Author), Bartel, Frank (Author), Blaydes, Jeremy P. (Author), Jochemsen, Aart G. (Author)
Format: Article
Language:English
Published: 2010-09-17.
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