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01273 am a22001573u 4500 |
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156351 |
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|a dc
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|a Richardson, Giles
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|a Cummings, Linda Jane
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|a Harris, H.J.
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|a O'Shea, Paul
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|a Toward a mathematical model of assembly and disassembly of membrane microdomains: comparison with experimental models
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|c 2007-06-15.
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|z Get fulltext
|u https://eprints.soton.ac.uk/156351/1/Biophysical%2520Journal%25202007%2520Richardson-1.pdf
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|a We study a model system in which lipid bilayers are created using variable (precisely known) proportions of phosphatidylcholine and cholesterol. The model membranes exhibit cholesterol-enriched microdomains that are analogous to the so-called "lipid rafts" that form in living cells. After briefly presenting some experimental results, we formulate and solve a novel mathematical model based on the Smoluchowski equations for coagulation and fragmentation. We present a comparison between the distribution of lipid-raft areas observed in experimental lipid bilayers, and that distribution predicted by the theoretical model. Excellent agreement between the experiments and theory is obtained, with minimal parameter fitting.
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