DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma

DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma

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Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis, and therapeutic treatment of oral squamous cel...

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Bibliographic Details
Main Authors: Froemming, G.R.A (Author), Khor, G.H (Author), Omar, E. (Author), Tan, A.C (Author), Tan, S.K (Author), Thomas Abraham, M. (Author), Thong, K.L (Author), Vincent-Chong, V.K (Author), Zain, R.B (Author)
Format: Article
Language:English
Subjects:
adult
Adult
age
aged
Aged
Aged, 80 and over
Amidohydrolases
article
cancer prognosis
Carcinoma, Squamous Cell
cheek mucosa
clinical article
controlled study
DDAH2
dimethylargininase
dimethylarginine dimethylamino hydrolase gene
DNA methylation
DNA Methylation
DNA methylation profiling
Dual Specificity Phosphatase 1
dual specificity phosphatase 1 gene
DUSP1
female
Female
Gene Expression Regulation, Neoplastic
gingiva
human
human tissue
Humans
immunohistochemistry
lip
male
Male
microarray analysis
Middle Aged
mitogen activated protein kinase phosphatase 1
Mouth Neoplasms
mouth squamous cell carcinoma
Neoplasm Proteins
Neoplasm Staging
Oral squamous cell carcinoma
Oral Squamous Cell Carcinoma
overall survival
p16 gene
polymerase chain reaction
promoter hypermethylation
Promoter hypermethylation
promoter region
Promoter Regions, Genetic
protein expression
Protein expression
protein expression.
protein p16
sex difference
Survival Analysis
survival rate
tongue
tumor localization
Tumor Markers, Biological
Online Access:View Fulltext in Publisher
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