Physical Function and Health-Related Quality of Life after Surgery for Nontuberculous Mycobacterium Pulmonary Disease: A Prospective Cohort Study

• Main Authors: Hiramatsu, M. (Author), Kimura, H. (Author), Kuroyama, Y. (Author), Omatsu, S. (Author), Senjyu, H. (Author), Shiraishi, Y. (Author), Tabusadani, M. (Author)
• Format: Article
• Language: English
• Published: NLM (Medline) 2022
• Subjects: aftercare; Aftercare; atypical mycobacteriosis; atypical Mycobacterium; exercise capacity; health-related quality of life; hospital discharge; human; Humans; lung disease; Lung Diseases; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; nontuberculous mycobacterium pulmonary disease; Patient Discharge; physical therapy; Prospective Studies; prospective study; quality of life; Quality of Life; questionnaire; surgical treatment; Surveys and Questionnaires; treatment outcome; Treatment Outcome
• Online Access: View Fulltext in Publisher
• ISBN: 21861005 (ISSN)
• DOI: 10.5761/atcs.oa.21-00125

PURPOSE: To investigate the exercise capacity and health-related quality of life (HRQOL) of surgical patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) preoperatively versus 6 months postoperatively. METHODS: This prospective observational study included patients with NTM-PD and was conducted at a single center. The intervention was surgical resection plus perioperative and post-discharge physical therapy. The physical function was assessed preoperatively and 6 months postoperatively using the 6-minute walk test (6MWT). HRQOL was assessed preoperatively and 6 months postoperatively using the Short-Form 36 (SF-36) health survey questionnaire and St. George's Respiratory Questionnaire. The postoperative HRQOL was compared between patients with and without preoperative clinical symptoms. RESULTS: In total, 35 patients were analyzed. The preoperatively symptomatic group had significantly lower preoperative HRQOL than the preoperatively asymptomatic group (p <0.05). Compared with preoperatively, there were significant improvements at 6 months postoperatively in the 6MWT (p <0.01) and HRQOL, mainly in the SF-36 mental component summary (p <0.01). The SF-36 mental component summary in the preoperatively symptomatic group was very significantly improved from preoperatively to 6 months postoperatively (p <0.05). CONCLUSION: The combination of surgical treatment and physical therapy for NTM-PD contributes to improvements in physical function and HRQOL.