The GLP-1 receptor agonist Exendin-4 modulates hippocampal NMDA-receptor signalling in aged rats and improves cognitive impairment in diabetic elderly patients

The GLP-1 receptor agonist Exendin-4 modulates hippocampal NMDA-receptor signalling in aged rats and improves cognitive impairment in diabetic elderly patients

Glucagon-like peptide-1 agonists (GLP-1A) are revolutionary drugs for the treatment of type 2 diabetes mellitus. Exendin-4 is an incretin agonist which shares 53% of GLP-1 amino-acid sequence and beyond its efficacy as antidiabetic, several studies demonstrated a neuroprotective effect in brain dama...

Full description

Bibliographic Details
Main Authors:	Cassano, T. (Author), Romano, A.D (Author), Sangineto, M. (Author), Serviddio, G. (Author), Villani, R. (Author)
Format:	Article
Language:	English
Published:	Pacini Editore S.p.A./AU-CNS 2022
Subjects:	cognitive impairment diabetes Exendin-4 GLP1 Hippocampus MMSE NMDA
Online Access:	View Fulltext in Publisher

Similar Items

Effect of the GLP-1 Analog Exendin-4 and Oxaliplatin on Intrahepatic Cholangiocarcinoma Cell Line and Mouse Model
by: Ben-Dong Chen, et al.
Published: (2013-12-01)

Increased co-expression of PSMA2 and GLP-1 receptor in cervical cancer models in type 2 diabetes attenuated by Exendin-4: A translational case-control study
by: Dandan Mao, et al.
Published: (2021-03-01)

Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes
by: Neil Tanday, et al.
Published: (2021-05-01)

Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9-39) in a normoglycemic mouse model
by: Haufe, Thomas Carl
Published: (2017)

GLP-1 REGULATES PROLIFERATION OF GLP-1 SECRETING CELLS THROUGH A FEEDBACK MECHANISM
by: Abdullahi Mohamed, Mohamed
Published: (2010)

Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4
by: Simon A. M. Kaeppeli, et al.
Published: (2019-05-01)

Involvement of hippocampal NMDA receptors in retention of shuttle avoidance conditioning in rats
by: Roesler R., et al.
Published: (1998-01-01)

[68Ga]Exendin-4: Bench-to-Bedside : PET molecular imaging of the GLP-1 receptor for diabetes and cancer
by: Selvaraju, Ram kumar
Published: (2015)

Long-Lasting Exendin-4 Fusion Protein Improves Memory Deficits in High-Fat Diet/Streptozotocin-Induced Diabetic Mice
by: Kyung-Ah Park, et al.
Published: (2020-02-01)

Radiosynthesis and evaluation of an 18F–labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma
by: Lukas O. Dialer, et al.
Published: (2018-01-01)

Stimulation of GLP-1 Receptor Inhibits Methylglyoxal-Induced Mitochondrial Dysfunctions in H9c2 Cardiomyoblasts: Potential Role of Epac/PI3K/Akt Pathway
by: Narawat Nuamnaichati, et al.
Published: (2020-05-01)

First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas
by: Hiroyuki Fujimoto, et al.
Published: (2021-08-01)

Repeated Restraint Stress Led to Cognitive Dysfunction by NMDA Receptor-Mediated Hippocampal CA3 Dendritic Spine Impairments in Juvenile Sprague-Dawley Rats
by: Dong-sheng Sun, et al.
Published: (2020-10-01)

Comprehensive analysis of LncRNAs expression profiles in an in vitro model of steatosis treated with Exendin-4
by: Khaoula Errafii, et al.
Published: (2021-06-01)

Afferent input selects NMDA receptor subtype to determine the persistency of hippocampal LTP in freely behaving mice
by: Jesús Javier Ballesteros, et al.
Published: (2016-10-01)

Hippocampal bursts caused by changes in NMDA receptor-dependent excitation in a mouse model of variant CJD
by: Stéphanie Ratté, et al.
Published: (2008-10-01)

Plant Polyphenols and Exendin-4 Prevent Hyperactivity and TNF-α Release in LPS-Treated In vitro Neuron/Astrocyte/Microglial Networks
by: Francesca Gullo, et al.
Published: (2017-09-01)

The Role of NMDA Receptor on Spatial Learning and Memory Consolidation Rat Following Intra-Hippocampal Injection of Aqueous Extract of Leaves of Origanum (Origanum Vulgare L. ssp. viridis)
by: Tahereh Haghpanah, et al.
Published: (2012-12-01)

Sigma-1 Receptor (σ – 1R) Activation and Modulation of NMDA Receptor Surface Expression
by: Hristova, Elitza
Published: (2014)

A Dual GLP-1/GIP Receptor Agonist Does Not Antagonize Glucagon at Its Receptor but May Act as a Biased Agonist at the GLP-1 Receptor
by: Noura Al-Zamel, et al.
Published: (2019-07-01)

Emerging role of GLP-1 receptor agonists in the treatment of obesity
by: Neff LM
Published: (2010-07-01)

Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
by: Joana S Ferreira, et al.
Published: (2017-06-01)

Development of schemas revealed by prior experience and NMDA receptor knock-out
by: George Dragoi, et al.
Published: (2013-12-01)

Systematic Design of Trypsin Cleavage Site Mutated Exendin4-Cysteine 1, an Orally Bioavailable Glucagon-Like Peptide-1 Receptor Agonist
by: Wenbo Sai, et al.
Published: (2017-03-01)

Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation
by: Shan-Shan Cui, et al.
Published: (2020-01-01)

GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects
by: Xin Zhao, et al.
Published: (2021-08-01)

Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity
by: Soraya Wilke Saliba, et al.
Published: (2019-12-01)

Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice
by: S.Y. Yau, et al.
Published: (2018-05-01)

Role of Exendin-4 in Brain Insulin Resistance, Mitochondrial Function, and Neurite Outgrowth in Neurons under Palmitic Acid-Induced Oxidative Stress
by: Danbi Jo, et al.
Published: (2021-01-01)

NMDA Receptor and Associated Intracellular Proteins in Amygdala and Hippocampus in Depression
by: Karolewicz, Beata, et al.
Published: (2006)

NMDA receptor function during senescence: implication on cognitive performance
by: Ashok eKumar
Published: (2015-12-01)

Exendin-4 for Parkinson's disease
by: Felipe de Jesús Esparza-Salazar, et al.
Published: (2021-01-01)

Novel Site-Specific Fatty Chain-Modified GLP-1 Receptor Agonist with Potent Antidiabetic Effects
by: Xia Zhong, et al.
Published: (2019-02-01)

Brain Site-Specific Inhibitory Effects of the GLP-1 Analogue Exendin-4 on Alcohol Intake and Operant Responding for Palatable Food
by: Kayla J. Colvin, et al.
Published: (2020-12-01)

Treatment-Resistant Major Depression:Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy
by: Charles eZorumski, et al.
Published: (2015-12-01)

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors
by: Franziska Hopfner, et al.
Published: (2019-04-01)

A Specific Role of Hippocampal NMDA Receptors and Arc Protein in Rapid Encoding of Novel Environmental Representations and a More General Long-Term Consolidation Function
by: Cameron M. Bye, et al.
Published: (2019-02-01)

Glucagon-Like Peptide-1 Analog Exendin-4 Ameliorates Cocaine-Mediated Behavior by Inhibiting Toll-Like Receptor 4 Signaling in Mice
by: Changliang Zhu, et al.
Published: (2021-07-01)

The dual amylin and calcitonin receptor agonist KBP-089 and the GLP-1 receptor agonist liraglutide act complimentarily on body weight reduction and metabolic profile
by: Anna Thorsø Larsen, et al.
Published: (2021-01-01)

Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology
by: Amanda J Mishizen-Eberz, et al.
Published: (2004-02-01)