Novel Compound Inhibitors of HIV-1NL4-3 Vpu

Novel Compound Inhibitors of HIV-1NL4-3 Vpu

HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate the contribution of Vpu to pathogenesis and lay th...

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Bibliographic Details
Main Authors: Ananthan, S. (Author), Augelli-Szafran, C.E (Author), Bostwick, R. (Author), Cai, Z. (Author), Evans, D.T (Author), Finzi, A. (Author), Gil, H.M (Author), Gupta, V.V (Author), Johnson, M.C (Author), Kuzmichev, Y.V (Author), Lyddon, T.D (Author), Nebane, N.M (Author), Ptak, R.G (Author), Rasmussen, L. (Author), Richard, J. (Author), Robinson, C.A (Author), Schader, S.M (Author), Welbourn, S. (Author), Wonderlich, E.R (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
bone marrow stromal antigen 2
Bone Marrow Stromal Antigen 2
GaLV
Gibbon ape leukemia virus
glycosylphosphatidylinositol anchored protein
GPI-Linked Proteins
HIV
HIV-1
HTS
Human immunodeficiency virus 1
Human immunodeficiency virus protein
Human Immunodeficiency Virus Proteins
inhibitors
Leukemia Virus, Gibbon Ape
metabolism
MLV
viral protein
Viral Regulatory and Accessory Proteins
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