| Summary: | Coronavirus disease (COVID-19), which affects the whole world, continues to spread. This disease has infected and killed millions of people worldwide. To limit the rate of spread of the disease, early detection should be provided and then the infected person should be quarantined. This paper proposes a Deep Learning-based application for early and accurate diagnosis of COVID-19. Compared to other studies, this application’s biggest difference and contribution are that it uses Tree Seed Algorithm (TSA)-optimized Artificial Neural Networks (ANN) to classify deep architectural features. Previous studies generally use fully connected layers for end-to-end learning classification. However, this study proves that even relatively simple AlexNet features can be classified more accurately with the TSA-ANN structure. The proposed hybrid model provides diagnosis with 98.54% accuracy for COVID-19 disease, which shows asymmetric distribution on Computed Tomography (CT) images. As a result, it is shown that using the proposed classification strategy, the features of end-to-end architectures can be classified more accurately. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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