Activation of Nrf2/HO-1 Antioxidant Pathway by Heme Attenuates Calcification of Human Lens Epithelial Cells

Activation of Nrf2/HO-1 Antioxidant Pathway by Heme Attenuates Calcification of Human Lens Epithelial Cells

Cataract, an opacification in the crystalline lens, is a leading cause of blindness. Deposition of hydroxyapatite occurs in a cataractous lens that could be the consequence of osteogenic differentiation of lens epithelial cells (LECs). Nuclear factor erythroid 2-related factor 2 (Nrf2) controls the...

Full description

Bibliographic Details
Main Authors:	Ababneh, H. (Author), Balogh, E. (Author), Chowdhury, A. (Author), Jeney, V. (Author), Tóth, A. (Author)
Format:	Article
Language:	English
Published:	MDPI 2022
Subjects:	cataract heme heme oxygenase-1 (HO-1) iron lens calcification lens epithelial cells nuclear factor erythroid 2-related factor 2 (Nrf2) osteogenic differentiation
Online Access:	View Fulltext in Publisher

Similar Items

Heme-Mediated Activation of the Nrf2/HO-1 Axis Attenuates Calcification of Valve Interstitial Cells
by: Enikő Balogh, et al.
Published: (2021-04-01)

Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury
by: Maria G. Detsika, et al.
Published: (2021-01-01)

Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop
by: Rui Li, et al.
Published: (2021-05-01)

Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
by: Jose Angel Alonso-Piñeiro, et al.
Published: (2021-09-01)

The protective effect of activating Nrf2 / HO-1 signaling pathway on cardiomyocyte apoptosis after coronary microembolization in rats
by: Jiabao Liang, et al.
Published: (2017-10-01)

The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway
by: Yoshiko Hada, et al.
Published: (2020-06-01)

Reduction of Oxidative Stress through Activating the Nrf2 mediated HO-1 Antioxidant Efficacy Signaling Pathway by MS15, an Antimicrobial Peptide from <i>Bacillus velezensis</i>
by: Md Maruf Khan, et al.
Published: (2020-09-01)

Epalrestat increases glutathione, thioredoxin, and heme oxygenase-1 by stimulating Nrf2 pathway in endothelial cells
by: Kaori Yama, et al.
Published: (2015-04-01)

DNA Protecting Activities of Nymphaea nouchali (Burm. f) Flower Extract Attenuate t-BHP-Induced Oxidative Stress Cell Death through Nrf2-Mediated Induction of Heme Oxygenase-1 Expression by Activating MAP-Kinases
by: Md Badrul Alam, et al.
Published: (2017-09-01)

Marine Microorganism-Derived Macrolactins Inhibit Inflammatory Mediator Effects in LPS-Induced Macrophage and Microglial Cells by Regulating BACH1 and HO-1/Nrf2 Signals through Inhibition of TLR4 Activation
by: Eun-Nam Kim, et al.
Published: (2020-02-01)

Ginsenoside Rg1 Protects Cardiomyocytes Against Hypoxia/Reoxygenation Injury via Activation of Nrf2/HO-1 Signaling and Inhibition of JNK
by: Qianhui Li, et al.
Published: (2017-11-01)

Ginsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling
by: Yunbo Shi, et al.
Published: (2018-01-01)

Punicalagin Protects Human Retinal Pigment Epithelium Cells from Ultraviolet Radiation-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway and Reducing Apoptosis
by: Maria Elisabetta Clementi, et al.
Published: (2020-06-01)

Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells
by: Joo-Heon Kim, et al.
Published: (2019-09-01)

Beta-1-Adrenergic Receptors Mediate Nrf2-HO-1-HMGB1 Axis Regulation to Attenuate Hypoxia/Reoxygenation-Induced Cardiomyocytes Injury in Vitro
by: Jichun Wang, et al.
Published: (2015-01-01)

Protective effect of Luteolin on oxidative damage of retinal pigment epithelium cells by regulating the Nrf2/HO-1 pathway
by: Meng Hong, et al.
Published: (2021-01-01)

High Resolution Mass Spectroscopy-Based Secondary Metabolite Profiling of <i>Nymphaea nouchali</i> (Burm. f) Stem Attenuates Oxidative Stress via Regulation of MAPK/Nrf2/HO-1/ROS Pathway
by: Md Badrul Alam, et al.
Published: (2021-05-01)

Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation
by: Chih-Chung Lin, et al.
Published: (2020-01-01)

Short ELF-EMF Exposure Targets SIRT1/Nrf2/HO-1 Signaling in THP-1 Cells
by: Patruno Antonia, et al.
Published: (2020-10-01)

Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
by: Valeria Consoli, et al.
Published: (2021-04-01)

α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage
by: Chengmei Lv, et al.
Published: (2017-10-01)

Pharmacological Targeting of Heme Oxygenase-1 in Osteoarthritis
by: Yohei Sanada, et al.
Published: (2021-03-01)

Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure
by: Valeria Sorrenti, et al.
Published: (2020-12-01)

Epigallocatechin 3-Gallate Has a Neuroprotective Effect in Retinas of Rabbits with Ischemia/Reperfusion through the Activation of Nrf2/HO-1
by: Josué Rivera-Pérez, et al.
Published: (2020-05-01)

Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1
by: Peijun Zhao, et al.
Published: (2018-12-01)

Relationship of Heme Oxygenase-1 (HO-1) Level with Onset and Severity in Normotensive Pregnancy and Severe Preeclampsia
by: John Johannes Wantania, et al.
Published: (2016-08-01)

CO-Releasing Molecule-2 Induces Nrf2/ARE-Dependent Heme Oxygenase-1 Expression Suppressing TNF-α-Induced Pulmonary Inflammation
by: Chih-Chung Lin, et al.
Published: (2019-03-01)

Suppression of 6-Hydroxydopamine-Induced Oxidative Stress by Hyperoside Via Activation of Nrf2/HO-1 Signaling in Dopaminergic Neurons
by: Seung-Hwan Kwon, et al.
Published: (2019-11-01)

Phytochemical Characterization of <i>Dillenia indica</i> L. Bark by Paper Spray Ionization-Mass Spectrometry and Evaluation of Its Antioxidant Potential Against t-BHP-Induced Oxidative Stress in RAW 264.7 Cells
by: Md Badrul Alam, et al.
Published: (2020-11-01)

Immune Modulation by Inhibitors of the HO System
by: Ayleen Fernández-Fierro, et al.
Published: (2021-12-01)

Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: An In Vitro and In Vivo Study
by: Susanna Fiorelli, et al.
Published: (2019-04-01)

Eckol Enhances Heme Oxygenase-1 Expression through Activation of Nrf2/JNK Pathway in HepG2 Cells
by: Young-Jin Jun, et al.
Published: (2014-09-01)

Marine Compound 3-Bromo-4,5-dihydroxybenzaldehyde Protects Skin Cells against Oxidative Damage via the Nrf2/HO-1 Pathway
by: Yea Seong Ryu, et al.
Published: (2019-04-01)

Glutamine Cooperatively Upregulates Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglial Cells through the ERK and Nrf-2/HO-1 Signaling Pathway
by: Rajapaksha Gedara Prasad Tharanga Jayasooriya, et al.
Published: (2020-06-01)

Dihydroquercetin Activates AMPK/Nrf2/HO-1 Signaling in Macrophages and Attenuates Inflammation in LPS-Induced Endotoxemic Mice
by: Liming Lei, et al.
Published: (2020-05-01)

Nrf2-Mediated HO-1 Induction Coupled with the ERK Signaling Pathway Contributes to Indirect Antioxidant Capacity of Caffeic Acid Phenethyl Ester in HepG2 Cells
by: Jin-Kyoung Kim, et al.
Published: (2014-07-01)

Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes
by: Hiroyuki Kanzaki, et al.
Published: (2016-08-01)

Inhibition of Fyn activates Nrf2 signaling pathway to attenuate oxidative stress injury after intracerebral hemorrhage in rats
by: ZHANG Li, et al.
Published: (2019-11-01)

Hawthorn Fruit Extract Elevates Expression of Nrf2/HO-1 and Improves Lipid Profiles in Ovariectomized Rats
by: Jeong-Hyun Yoo, et al.
Published: (2016-05-01)

Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne
by: Masutaka Furue, et al.
Published: (2018-07-01)

Cannot write session to /tmp/vufind_sessions/sess_9hsnd97fst99no0i9emr98hbah