Inhibition of Vascular Endothelial Cadherin Cleavage Prevents Elastic Fiber Alterations and Atherosclerosis Induced by Intermittent Hypoxia in the Mouse Aorta

Inhibition of Vascular Endothelial Cadherin Cleavage Prevents Elastic Fiber Alterations and Atherosclerosis Induced by Intermittent Hypoxia in the Mouse Aorta

Intermittent hypoxia (IH), the major feature of obstructive sleep apnea syndrome (OSAS), induces atherosclerosis and elastic fiber alterations. VE-cadherin cleavage is increased in OSAS patients and in an IH-cellular model. It is mediated by HIF-1 and Src-tyr-kinases pathways and results in endothel...

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Bibliographic Details
Main Authors: Arco-Hierves, A. (Author), Bouyon, S. (Author), Briançon-Marjollet, A. (Author), Chirica, C. (Author), Demory, A. (Author), Faury, G. (Author), Harki, O. (Author), Lemarié, E. (Author), Pépin, J.-L (Author), Sallé, M. (Author), Vilgrain, I. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
atherosclerosis
elastic fiber fragmentation
endothelial dysfunction
intermittent hypoxia
obstructive sleep apnea syndrome
VE-cadherin
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