Physosmotic Induction of Chondrogenic Maturation Is TGF-β Dependent and Enhanced by Calcineurin Inhibitor FK506

Physosmotic Induction of Chondrogenic Maturation Is TGF-β Dependent and Enhanced by Calcineurin Inhibitor FK506

Increasing extracellular osmolarity 100 mOsm/kg above plasma level to the physiological levels for cartilage induces chondrogenic marker expression and the differentiation of chondroprogenitor cells. The calcineurin inhibitor FK506 has been reported to modulate the hypertrophic differentiation of pr...

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Bibliographic Details
Main Authors: Baart, E.B (Author), Jahr, H. (Author), Lian, W.-S (Author), Pufe, T. (Author), Rolauffs, B. (Author), Timur, U.T (Author), van der Windt, A.E (Author), Wang, F.-S (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
ATDC5
BMP signaling
calcineurin
chondrocyte
differentiation
FK506
FKBP-12
hyperosmolarity
minor collagens
TGFBI
Online Access:View Fulltext in Publisher

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