Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates

Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates

The human gonadotropin releasing hormone (GnRH-I) and its sea lamprey analogue GnRH-III specifically bind to GnRH receptors on cancer cells and can be used as targeting moieties for targeted tumor therapy. Considering that the selective release of drugs in cancer cells is of high relevance, we were...

Full description

Bibliographic Details
Main Authors:	Gennari, C. (Author), Halmos, G. (Author), Juhász, É (Author), Mező, G. (Author), Neundorf, I. (Author), Schuster, S. (Author)
Format:	Article
Language:	English
Published:	MDPI 2022
Subjects:	antitumor activity cathepsin B daunorubicin drug delivery system gonadotropin releasing hormone paclitaxel peptide-drug conjugates SMDC targeted cancer therapy
Online Access:	View Fulltext in Publisher

Similar Items

Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification
by: Sabine Schuster, et al.
Published: (2018-11-01)

Apoptotic Effects of Drug Targeting Conjugates Containing Different GnRH Analogs on Colon Carcinoma Cells
by: Eszter Lajkó, et al.
Published: (2019-09-01)

Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice
by: Ivan Ranđelović, et al.
Published: (2019-09-01)

Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin–GnRH-III conjugates developed for targeted drug delivery
by: Sabine Schuster, et al.
Published: (2018-04-01)

Suitability of GnRH Receptors for Targeted Photodynamic Therapy in Head and Neck Cancers
by: Lilla Pethő, et al.
Published: (2019-10-01)

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids
by: Eszter Lajkó, et al.
Published: (2018-09-01)

Differential roles of GnRH-I and GnRH-II neurons in the control of the primate reproductive axis
by: Henryk eUrbanski
Published: (2012-02-01)

GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors
by: Samantha Sperduti, et al.
Published: (2019-11-01)

GnRH agonist versus GnRH antagonist in assisted reproduction cycles: oocyte morphology
by: Cota Ana Marcia M, et al.
Published: (2012-04-01)

Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding
by: Colleen A. Flanagan, et al.
Published: (2017-10-01)

The Influence of Self Management Dietary Counseling on The Value of Sodium and Edema in Hemodialysis Patients
by: Faradisa Yuanita Fahmi, et al.
Published: (2019-02-01)

Novel Crizotinib–GnRH Conjugates Revealed the Significance of Lysosomal Trapping in GnRH-Based Drug Delivery Systems
by: József Murányi, et al.
Published: (2019-11-01)

Effect of Endometrium Thickness on Clinical Outcomes in Luteal Phase Short-Acting GnRH-a Long Protocol and GnRH-Ant Protocol
by: Jie Zhang, et al.
Published: (2021-05-01)

Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells
by: Livia Polgár, et al.
Published: (2018-06-01)

Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer
by: Carsten Gründker, et al.
Published: (2021-02-01)

Introduction to special topic - Estrogenic control of hypothalamic GnRH neurons
by: Henryk F. Urbanski
Published: (2012-11-01)

The Cellular Localization of GnRH and LHR in Aged Female Mice
by: Young-Jong Kim, et al.
Published: (2018-12-01)

Studies On Cloning And Characterization Of GnRH Receptor From The Pituitary Of Bonnet Monkey (Macaca Radiata) And Functional Studies With The Antiserum To GnRH Receptor
by: Santra, Sumana
Published: (2005)

Study on the performance of gonadotropin- releasing hormone (GnRH) in the puerperal period of beef cows
by: Maslev Ts., et al.
Published: (2014-01-01)

The Role of Gonadotropin-Releasing Hormone (GnRH) in Endometrial Cancer
by: Günter Emons, et al.
Published: (2021-02-01)

Synthesis and Preliminary Anticancer Evaluation of 6-Mercaptopurine –Methotrexate Conjugate as Possible Mutual Prodrug
by: Asmaa S. Al-Darraji, et al.
Published: (2019-06-01)

GnRH/GnIH e seus receptores no sistema olfato-retinal de zebrafish /
by: Corchuelo Chavarro, Sheryll Yohana.
Published: (2015)

GnRH/GnIH e seus receptores no sistema olfato-retinal de zebrafish
by: Corchuelo Chavarro, Sheryll Yohana [UNESP]
Published: (2016)

Deciphering Direct and Indirect Effects of Neurokinin B and GnRH in the Brain-Pituitary Axis of Tilapia
by: Naama Mizrahi, et al.
Published: (2019-07-01)

Semaphorin Signaling in the Development and Function of the Gonadotropin Hormone-Releasing Hormone (GnRH) System
by: Andrea eMessina, et al.
Published: (2013-09-01)

Cumulative live birth rates between GnRH-agonist long and GnRH-antagonist protocol in one ART cycle when all embryos transferred: real-word data of 18,853 women from China
by: Jingwei Yang, et al.
Published: (2021-08-01)

To compare the effect of GnRH agonist versus human chorionic gonadotropin (HCG) trigger on clinical pregnancy rate in intrauterine insemination cycle
by: Rashmi Sharma, et al.
Published: (2021-01-01)

Using Aptamers as a Novel Method for Determining GnRH/LH Pulsatility
by: Chioma Izzi-Engbeaya, et al.
Published: (2020-10-01)

The Synthesis and Preliminary Anticancer Evaluation of 6-Mercaptopurine -Methotrexate Conjugate as Possible Mutual Prodrug
by: Asmaa Safwan Al-darraji, et al.
Published: (2019-06-01)

Characterization of Gonadotropin-Releasing Hormone (GnRH) Genes From Cartilaginous Fish: Evolutionary Perspectives
by: Anne-Laure Gaillard, et al.
Published: (2018-09-01)

Sexual Dimorphic Distribution of Hypothalamic Tachykinin1 Cells and Their Innervations to GnRH Neurons in the Zebrafish
by: Satoshi Ogawa, et al.
Published: (2021-03-01)

Short, semi-short or long GnRH agonist treatment regimens in women ICSI candidate; which is proper in
by: Popea Rezaeian, et al.
Published: (2016-09-01)

GnRH Immunocontraception of Male and Female White-Tailed Deer Fawns
by: Lowell A. Miller, et al.
Published: (2017-02-01)

A Novel Nomogram for Individualized Gonadotropin Starting Dose in GnRH Antagonist Protocol
by: Yubin Li, et al.
Published: (2021-09-01)

Liposomal daunorubicin and dexamethasone as a treatment for multiple myeloma: the DD Protocol
by: Frederico Luiz Dulley, et al.

Leptin and adiponectin levels in girls with central precocious puberty before and during GnRH agonist treatment
by: Jae Won Yoo, et al.
Published: (2016-12-01)

Pregnancy outcome in delayed start antagonist versus microdose flare GnRH agonist protocol in poor responders undergoing IVF/ICSI: An RCT
by: Robab Davar, et al.
Published: (2018-04-01)

GnRH-Related Neurohormones in the Fruit Fly <i>Drosophila melanogaster</i>
by: David Ben-Menahem
Published: (2021-05-01)

Effect of GnRH-a on HOXA10 expression in eutopic endometrial cells of endometriosis
by: Sha Yu, et al.
Published: (2016-02-01)

Oxidative stress and biochemical markers in prenatally androgenized sheep after neonatal treatment with GnRH agonist
by: Nóbrega JE, et al.
Published: (2019-03-01)

Cannot write session to /tmp/vufind_sessions/sess_qp1e9krcnbr9cesqhrno2jtju3