The Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression

The Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression

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Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer with limited therapeutic options and short overall survival. iCCA is characterized by a strong desmoplastic reaction in the surrounding ecosystem that likely affects tumoral progression. Overexpression of the Notch pathway is impli...

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Bibliographic Details
Main Authors: Ardito, F. (Author), Armentano, R. (Author), Coletta, S. (Author), Dituri, F. (Author), Fabregat, I. (Author), Giannelli, G. (Author), Mancarella, S. (Author), Ruzzenente, A. (Author), Serino, G. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
gene expression
HuCCT1-xenograft mouse model
intrahepatic cholangiocarcinoma
microenvironment
NOTCH1
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