PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis

• Main Authors: Bajzik, G. (Author), Barsi, P. (Author), Beyer, T. (Author), Borbély, K. (Author), Dóczi, T. (Author), Emri, M. (Author), Fabó, D. (Author), Fajtai, D. (Author), Janszky, J. (Author), Jordán, Z. (Author), Juhos, V. (Author), Kelemen, A. (Author), Kenessey, I. (Author), Lückl, J. (Author), Moizs, M. (Author), Nagy, D. (Author), Nagy, F. (Author), Pál, E. (Author), Repa, I. (Author), Singer, J. (Author), Tóth, M. (Author), Tóth, Z. (Author), Vajda, Z. (Author), Wintermark, M. (Author)
• Format: Article
• Language: English
• Published: MDPI 2022
• Subjects: concordance analysis; discordant electroclinical and MRI data; epilepsy surgery; epilepsy team; hybrid [18F]-FDG PET/MRI; medically refractory focal epilepsy; metabolic PET; MRI-negative patients; preoperative workflow; presurgical evaluation
• Online Access: View Fulltext in Publisher

 The aim of our prospective study was to evaluate the clinical impact of hybrid [18F]-fluoro-deoxyglucose positron emission tomography/magnetic resonance imaging ([18F]-FDG PET/MRI) on the decision workflow of epileptic patients with discordant electroclinical and MRI data. A novel mathematical model was introduced for a clinical concordance calculation supporting the classifi-cation of our patients by subgroups of clinical decisions. Fifty-nine epileptic patients with discordant clinical and diagnostic results or MRI negativity were included in this study. The diagnostic value of the PET/MRI was compared to other modalities of presurgical evaluation (e.g., electroclin-ical data, PET, and MRI). The results of the population-level statistical analysis of the introduced data fusion technique and concordance analysis demonstrated that this model could be the basis for the development of a more accurate clinical decision support parameter in the future. Therefore, making the establishment of “invasive” (operable and implantable) and “not eligible for any further invasive procedures” groups could be much more exact. Our results confirmed the relevance of PET/MRI with the diagnostic algorithm of presurgical evaluation. The introduction of a concordance analysis could be of high importance in clinical and surgical decision-making in the management of epileptic patients. Our study corroborated previous findings regarding the advantages of hybrid PET/MRI technology over MRI and electroclinical data. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.