PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis

PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis

PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores causing tumor cell lysis and necrosis. Conformational...

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Bibliographic Details
Main Authors: Bowne, W.B (Author), Cheung, D. (Author), Frenkel, M. (Author), Fridman, D. (Author), Lin, B. (Author), Michl, J. (Author), Morano, W.F (Author), Mumin, S. (Author), Pincus, M.R (Author), Rosal, R. (Author), Rudolph, R. (Author), Sarafraz-Yazdi, E. (Author), Thadi, A. (Author), Wong, L. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
cell-penetrating peptides (CPP)
HDM-2/MDM-2
p53 binding domain
plasma membrane pore formation
PNC-27
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